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Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralising Potency and Multifunctionality, Generated for Therapeutic Development

dc.contributor.authorUbah, Obinna C.
dc.contributor.authorSteven, John
dc.contributor.authorKovaleva, Marina
dc.contributor.authorFerguson, Laura
dc.contributor.authorBarelle, Charlotte
dc.contributor.authorPorter, Andrew J. R.
dc.contributor.authorBarelle, Caroline J.
dc.date.accessioned2018-01-03T11:46:05Z
dc.date.available2018-01-03T11:46:05Z
dc.date.issued2017-12-22
dc.identifier113455428
dc.identifier0a203d74-8ff7-489e-87c5-a8e88b2eadf6
dc.identifier85038923529
dc.identifier.citationUbah , O C , Steven , J , Kovaleva , M , Ferguson , L , Barelle , C , Porter , A J R & Barelle , C J 2017 , ' Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralising Potency and Multifunctionality, Generated for Therapeutic Development ' , Frontiers in Immunology , vol. 8 , 1780 . https://doi.org/10.3389/fimmu.2017.01780en
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/2164/9849
dc.descriptionACKNOWLEDGMENTS The authors wish to acknowledge the funding support for this work from MSD/Scottish Universities Life Sciences Alliance (SULSA), Scottish Enterprise, the Biotechnology and Biological Sciences Research Council (BBSRC), and the University of Aberdeen. FUNDING Grateful for support from Biotechnology and Biological Sciences Research Council (BB/K010905/1), Scottish Enterprise [VNAR_001 (2012)], Scottish Universities Life Sciences Alliance/ MSD (MSD01_A_Porter-Teismann), and the College of Life Sciences and Medicine, University of Aberdeen (Fee bursary to OU).en
dc.format.extent13
dc.format.extent1344258
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunologyen
dc.subjectvNARen
dc.subjectTNF-αen
dc.subjectphage displayen
dc.subjectcytokine neutralisationen
dc.subjectchronic inflammationen
dc.subjectshark IgNARen
dc.subjectbiparatopic/bispecific binding domainen
dc.subjectanti-TNF biologicsen
dc.subjectshark immunisationen
dc.subjectsingle binding domainen
dc.subjectvariable new antigen receptoren
dc.subjecttumor necrosis factor-αen
dc.subjectbinding domainen
dc.subjectQR180 Immunologyen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K010905/1en
dc.subject.lccQR180en
dc.titleNovel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralising Potency and Multifunctionality, Generated for Therapeutic Developmenten
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.3389/fimmu.2017.01780
dc.identifier.vol8en


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