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In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

dc.contributor.authorSteven, John
dc.contributor.authorMüller, Mischa R
dc.contributor.authorCarvalho, Miguel F
dc.contributor.authorUbah, Obinna C
dc.contributor.authorKovaleva, Marina
dc.contributor.authorDonohoe, Gerard
dc.contributor.authorBaddeley, Thomas
dc.contributor.authorCornock, Dawn
dc.contributor.authorSaunders, Kenneth
dc.contributor.authorPorter, Andrew J
dc.contributor.authorBarelle, Caroline Jane
dc.date.accessioned2017-11-15T10:24:07Z
dc.date.available2017-11-15T10:24:07Z
dc.date.issued2017-10-23
dc.identifier111529586
dc.identifierf9d656ab-df58-435b-9492-5e5aa9ae4f8e
dc.identifier29109729
dc.identifier85032194831
dc.identifier.citationSteven , J , Müller , M R , Carvalho , M F , Ubah , O C , Kovaleva , M , Donohoe , G , Baddeley , T , Cornock , D , Saunders , K , Porter , A J & Barelle , C J 2017 , ' In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development ' , Frontiers in Immunology , vol. 8 , 1361 . https://doi.org/10.3389/fimmu.2017.01361en
dc.identifier.issn1664-3224
dc.identifier.otherPubMedCentral: PMC5660122
dc.identifier.urihttp://hdl.handle.net/2164/9601
dc.descriptionAcknowledgments: The authors would like to acknowledge the funding support for this work from Scottish Enterprise [VNAR_001(2012)] and the Biotechnology and Biological Sciences Research Council (BB/K010905/1).en
dc.format.extent3633485
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunologyen
dc.subjectJournal Articleen
dc.subjectVNARen
dc.subjectsoloMERen
dc.subjectsingle chain binding domainen
dc.subjectSharken
dc.subjecthumanizationen
dc.subjecthalf-life extensionen
dc.subjectpharmacokineticsen
dc.subjectQD Chemistryen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K010905/1en
dc.subject.lccQDen
dc.titleIn Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Developmenten
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.3389/fimmu.2017.01361


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