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Genome-wide Association for Major Depression Through Age at Onset Stratification : Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

dc.contributor.authorPower, Robert A
dc.contributor.authorTansey, Katherine E
dc.contributor.authorButtenschøn, Henriette Nørmølle
dc.contributor.authorCohen-Woods, Sarah
dc.contributor.authorBigdeli, Tim
dc.contributor.authorHall, Lynsey S
dc.contributor.authorKutalik, Zoltán
dc.contributor.authorLee, S Hong
dc.contributor.authorRipke, Stephan
dc.contributor.authorSteinberg, Stacy
dc.contributor.authorTeumer, Alexander
dc.contributor.authorViktorin, Alexander
dc.contributor.authorWray, Naomi R
dc.contributor.authorArolt, Volker
dc.contributor.authorBaune, Bernard T
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorBørglum, Anders D
dc.contributor.authorByrne, Enda M
dc.contributor.authorCastelao, Enrique
dc.contributor.authorCraddock, Nick
dc.contributor.authorCraig, Ian W
dc.contributor.authorDannlowski, Udo
dc.contributor.authorDeary, Ian J
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorForstner, Andreas J
dc.contributor.authorGordon, Scott D
dc.contributor.authorGrabe, Hans J
dc.contributor.authorGrove, Jakob
dc.contributor.authorHamilton, Steven P
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeath, Andrew C
dc.contributor.authorHocking, Lynne J
dc.contributor.authorHomuth, Georg
dc.contributor.authorHottenga, Jouke J
dc.contributor.authorKloiber, Stefan
dc.contributor.authorKrogh, Jesper
dc.contributor.authorLandén, Mikael
dc.contributor.authorLang, Maren
dc.contributor.authorLevinson, Douglas F
dc.contributor.authorLichtenstein, Paul
dc.contributor.authorLucae, Susanne
dc.contributor.authorMacIntyre, Donald J
dc.contributor.authorMadden, Pamela
dc.contributor.authorMagnusson, Patrik K E
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMiddeldorp, Christel M
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorMors, Ole
dc.contributor.authorCONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium
dc.date.accessioned2017-08-30T11:00:17Z
dc.date.available2017-08-30T11:00:17Z
dc.date.issued2017-02-15
dc.identifier107335686
dc.identifier45a462c1-59f5-4a45-a8f8-587515c1231e
dc.identifier27519822
dc.identifier84994229145
dc.identifier.citationPower , R A , Tansey , K E , Buttenschøn , H N , Cohen-Woods , S , Bigdeli , T , Hall , L S , Kutalik , Z , Lee , S H , Ripke , S , Steinberg , S , Teumer , A , Viktorin , A , Wray , N R , Arolt , V , Baune , B T , Boomsma , D I , Børglum , A D , Byrne , E M , Castelao , E , Craddock , N , Craig , I W , Dannlowski , U , Deary , I J , Degenhardt , F , Forstner , A J , Gordon , S D , Grabe , H J , Grove , J , Hamilton , S P , Hayward , C , Heath , A C , Hocking , L J , Homuth , G , Hottenga , J J , Kloiber , S , Krogh , J , Landén , M , Lang , M , Levinson , D F , Lichtenstein , P , Lucae , S , MacIntyre , D J , Madden , P , Magnusson , P K E , Martin , N G , McIntosh , A M , Middeldorp , C M , Milaneschi , Y , Montgomery , G W , Mors , O & CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium 2017 , ' Genome-wide Association for Major Depression Through Age at Onset Stratification : Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium ' , Biological Psychiatry , vol. 81 , no. 4 , pp. 325-335 . https://doi.org/10.1016/j.biopsych.2016.05.010en
dc.identifier.issn0006-3223
dc.identifier.otherPubMedCentral: PMC5262436
dc.identifier.urihttp://hdl.handle.net/2164/9229
dc.descriptionThe PGC was funded by National Institute of Mental Health (NIMH) Grant Nos. MH085520 (to PFS) and MH080403. Statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and financially supported by the Netherlands Scientific Organization Grant No. NWO 480-05-003 (to D. Posthuma) and the department of Psychology, Vrije Universiteit Amsterdam along with a supplement from the Dutch Brain Foundation. The Bonn/Mannheim GWAS was supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Genome Research Network Systematic Investigation of the Molecular Causes of Major Mood Disorders and Schizophrenia Grant Nos. 01GS08144 and 01GS08147, under the auspices of the National Genome Research Network plus, and through the Integrated Network Integrated Understanding of Causes and Mechanisms in Mental Disorders, under the auspices of the e:Med Programme Grant Nos. 01ZX1314A and 01ZX1314G. The Bonn/Mannheim GWAS was also supported by the German Research Foundation (DFG) Grant Nos. FOR2107, RI908/11-1, and NO246/10-1. The GenRED GWAS project was supported by NIMH R01 Grant Nos. MH061686 (to DFL), MH059542 (to W.H. Coryell), MH075131 (W.B. Lawson), MH059552 (JBP), MH059541 (W.A. Scheftner), and MH060912 (MMW). Max Planck Institute of Psychiatry MARS study was supported by the BMBF Program Molecular Diagnostics: Validation of Biomarkers for Diagnosis and Outcome in Major Depression by Grant No. 01ES0811. Genotyping was supported by the Bavarian Ministry of Commerce, and the BMBF in the framework of the National Genome Research Network by Grant Nos. NGFN2 and NGFN-Plus, FKZ 01GS0481 and 01GS08145. The Netherlands Study of Depression and Anxiety and the Netherlands Twin Register contributed to Genetic Association Information Network (GAIN)-MDD and to MDD2000. Funding for NTR/NESDA was from the following: the Netherlands Organization for Scientific Research (MagW/ZonMW Grant Nos. 904-61-090, 985-10- 002, 904-61-193, 480-04-004, 400-05-717, 912-100-20; Spinozapremie Grant No. 56-464-14192; Geestkracht program Grant No. 10-000-1002); the Center for Medical Systems Biology (NWO Genomics), Biobanking and Biomolecular Resources Research Infrastructure, Vrije Universiteit’s Institutes for Health and Care Research and Neuroscience Campus Amsterdam, BIC/BioAssist/RK (Grant No. 2008.024); the European Science Foundation (Grant No. EU/QLRT-2001-01254); the European Community’s Seventh Framework Program (Grant No. FP7/2007-2013); ENGAGE (Grant No. HEALTH-F4-2007-201413); and the European Science Council (Grant No. ERC 230374). Genotyping was funded in part by the GAIN of the Foundation for the US National Institutes of Health, and analysis was supported by grants from GAIN and the NIMH (Grant No. MH081802). Funding for the QIMR samples was provided by the Australian National Health and Medical Research Council (Grant Nos. 241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496675, 496739, 552485, 552498, 613602, 613608, 613674, 619667), the Australian Research Council (Grant Nos. FT0991360, FT0991022), the FP-5 GenomEUtwin Project (Grant No. QLG2-CT-2002-01254), and the US National Institutes of Health (Grant Nos. AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, MH66206, DA12854, DA019951), and the Center for Inherited Disease Research (Baltimore, MD). RADIANT was funded by the following: a joint grant from the UK Medical Research Council and GlaxoSmithKline (Grant No. G0701420); the National Institute for Health Research Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley National Health Service Foundation Trust and the Institute of Psychiatry, King’s College London; the UK Medical Research Council (Grant No. G0000647), and the Marie Curie Industry-Academia Partnership and Pathways (Grant No. 286213). The GENDEP study was funded by a European Commission Framework 6 grant (EC Contract Ref.: LSHB-CT-2003-503428). Genotyping of STAR*D was supported by NIMH Grant No. MH072802 (to SPH). STAR*D was funded by NIMH Grant No. N01MH90003 to the University of Texas Southwestern Medical Center at Dallas (to A.J. Rush). The CoLaus/PsyCoLaus study was supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and the Swiss National Science Foundation (Grant Nos. 3200B0–105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468, 33CS30-148401) and two grants from GlaxoSmithKline Clinical Genetics. SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (Grant Nos. 01ZZ9603, 01ZZ0103, 01ZZ0403), the Ministry of Cultural Affairs, and the Social Ministry of the Federal State of Mecklenburg–West Pomerania. Genome-wide data have been supported by the Federal Ministry of Education and Research (Grant No. 03ZIK012) and a joint grant from Siemens Healthcare, Erlangen, Germany, and the Federal State of Mecklenburg–West Pomerania. SHIP-LEGEND is funded by the DFG (Grant No. GR 1912/5-1). The TwinGene study was supported by the Swedish Ministry for Higher Education, the Swedish Research Council (Grant No. M-2005-1112), GenomEUtwin (Grant Nos. EU/QLRT-2001-01254, QLG2-CT-2002-01254), the Swedish Foundation for Strategic Research and the US National Institutes of Health (Grant No. U01 DK066134). The collection of PRISME control subjects and genotyping of the 883 Danish control subjects was supported by grants from The Danish Strategic Research Council, The Stanley Research Foundation, and H. Lundbeck A/S. The Muenster Depression cohorts were supported by the European Union (Grant No. N Health-F2-2008-222963) and by grants from the DFG (Grant Nos. FOR 2107 and DA1151/5-1 [to UD]), Innovative Medizinische Forschung of the Medical Faculty of Mu¨nster (Grant Nos. DA120903, DA111107, and DA211012 [all to UD]). Generation Scotland is supported by a Wellcome Trust Strategic Award “Stratifying Resilience and Depression Longitudinally” (Reference No.: 104036/Z/14/Z) and core support from the Chief Scientist Office of the Scottish Government Health Directorates (Grant No. CZD/16/6) and the Scottish Funding Council (Grant No. HR03006). Supplementary material cited in this article is available online at http:// dx.doi.org/10.1016/j.biopsych.2016.05.010.en
dc.format.extent11
dc.format.extent784070
dc.language.isoeng
dc.relation.ispartofBiological Psychiatryen
dc.subjectGWASen
dc.subjectAge at onseten
dc.subjectHeterogeneityen
dc.subjectMajor depressive disorderen
dc.subjectPolygenic scoringen
dc.subjectStratificationen
dc.subjectJournal Articleen
dc.subjectQH426 Geneticsen
dc.subjectEuropean Commissionen
dc.subjectLSHB-CT-2003-503428en
dc.subjectMedical Research Council (MRC)en
dc.subjectG0701420en
dc.subjectG0000647en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subject.lccQH426en
dc.titleGenome-wide Association for Major Depression Through Age at Onset Stratification : Major Depressive Disorder Working Group of the Psychiatric Genomics Consortiumen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.identifier.doi10.1016/j.biopsych.2016.05.010


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