dc.contributor.author | Koss, David J. | |
dc.contributor.author | Jones, Glynn | |
dc.contributor.author | Cranston, Anna | |
dc.contributor.author | Gardner, Heidi | |
dc.contributor.author | Kanaan, Nicholas M. | |
dc.contributor.author | Platt, Bettina | |
dc.date.accessioned | 2016-10-25T14:28:21Z | |
dc.date.available | 2016-10-25T14:28:21Z | |
dc.date.issued | 2016-12-01 | |
dc.identifier.citation | Koss , D J , Jones , G , Cranston , A , Gardner , H , Kanaan , N M & Platt , B 2016 , ' Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline ' , Acta Neuropathologica , vol. 132 , no. 6 , pp. 875–895 . https://doi.org/10.1007/s00401-016-1632-3 | en |
dc.identifier.issn | 0001-6322 | |
dc.identifier.other | PURE: 71903039 | |
dc.identifier.other | PURE UUID: 455fb6e8-2d0f-47a9-a976-e483e5cafe68 | |
dc.identifier.other | Scopus: 84992070777 | |
dc.identifier.other | ORCID: /0000-0002-7852-0749/work/76976884 | |
dc.identifier.uri | http://hdl.handle.net/2164/7589 | |
dc.description | Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the Alzheimer’s Society and the Medical Research Council, and sourced from the MRC London Neurodegenerative Diseases Brain Bank, the Manchester Brain Bank, the South West Dementia Brain Bank (SWDBB), the Newcastle Brain Tissue Resource and the Oxford Brain Bank. The Newcastle Brain Tissue Resource and Oxford Brain Bank are also supported by the National Institute for Health Research (NIHR) Units. The South West Dementia Brain Bank (SWDBB) receives additional support from BRACE (Bristol Research into Alzheimer’s and Care of the Elderly). Alz-50, CP13, MC-1 and PHF-1 antibodies were gifted from Dr. Peter Davies and brain lystates from BACE1−/−mice were obtained from Prof Mike Ashford. The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUKPPG2014A-21 and ARUK-NSG2015-1 to BP and DK and NIH/NIA grants NIH/NINDS R01 NS082730 and R01 AG044372 to NK) | en |
dc.format.extent | 21 | |
dc.language.iso | eng | |
dc.relation.ispartof | Acta Neuropathologica | en |
dc.rights | © The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject | Alzheimer’s disease | en |
dc.subject | amyloid | en |
dc.subject | tau | en |
dc.subject | cognitive decline | en |
dc.subject | dementia | en |
dc.subject | pathology | en |
dc.subject | R Medicine | en |
dc.subject | Alzheimers Research UK | en |
dc.subject | ARUKPPG2014A-21 | en |
dc.subject | ARUK-NSG2015-1 | en |
dc.subject | Medical Research Council (MRC) | en |
dc.subject | National Institute for Health Research (NIHR) | en |
dc.subject | R01 NS082730 | en |
dc.subject | R01 AG044372 | en |
dc.subject | Supplementary Data | en |
dc.subject.lcc | R | en |
dc.title | Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Institute of Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Health Services Research Unit | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Publisher PDF | en |
dc.identifier.doi | https://doi.org/10.1007/s00401-016-1632-3 | |