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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

dc.contributor.authorKoss, David J.
dc.contributor.authorJones, Glynn
dc.contributor.authorCranston, Anna
dc.contributor.authorGardner, Heidi
dc.contributor.authorKanaan, Nicholas M.
dc.contributor.authorPlatt, Bettina
dc.date.accessioned2016-10-25T14:28:21Z
dc.date.available2016-10-25T14:28:21Z
dc.date.issued2016-12-01
dc.identifier.citationKoss , D J , Jones , G , Cranston , A , Gardner , H , Kanaan , N M & Platt , B 2016 , ' Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline ' , Acta Neuropathologica , vol. 132 , no. 6 , pp. 875–895 . https://doi.org/10.1007/s00401-016-1632-3en
dc.identifier.issn0001-6322
dc.identifier.otherPURE: 71903039
dc.identifier.otherPURE UUID: 455fb6e8-2d0f-47a9-a976-e483e5cafe68
dc.identifier.otherScopus: 84992070777
dc.identifier.otherORCID: /0000-0002-7852-0749/work/76976884
dc.identifier.urihttp://hdl.handle.net/2164/7589
dc.descriptionAcknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the Alzheimer’s Society and the Medical Research Council, and sourced from the MRC London Neurodegenerative Diseases Brain Bank, the Manchester Brain Bank, the South West Dementia Brain Bank (SWDBB), the Newcastle Brain Tissue Resource and the Oxford Brain Bank. The Newcastle Brain Tissue Resource and Oxford Brain Bank are also supported by the National Institute for Health Research (NIHR) Units. The South West Dementia Brain Bank (SWDBB) receives additional support from BRACE (Bristol Research into Alzheimer’s and Care of the Elderly). Alz-50, CP13, MC-1 and PHF-1 antibodies were gifted from Dr. Peter Davies and brain lystates from BACE1−/−mice were obtained from Prof Mike Ashford. The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUKPPG2014A-21 and ARUK-NSG2015-1 to BP and DK and NIH/NIA grants NIH/NINDS R01 NS082730 and R01 AG044372 to NK)en
dc.format.extent21
dc.language.isoeng
dc.relation.ispartofActa Neuropathologicaen
dc.rights© The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAlzheimer’s diseaseen
dc.subjectamyloiden
dc.subjecttauen
dc.subjectcognitive declineen
dc.subjectdementiaen
dc.subjectpathologyen
dc.subjectR Medicineen
dc.subjectAlzheimers Research UKen
dc.subjectARUKPPG2014A-21en
dc.subjectARUK-NSG2015-1en
dc.subjectMedical Research Council (MRC)en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectR01 NS082730en
dc.subjectR01 AG044372en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleSoluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive declineen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Health Services Research Uniten
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1007/s00401-016-1632-3


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