Show simple item record

Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice

dc.contributor.authorXu, Pingwen
dc.contributor.authorHe, Yanlin
dc.contributor.authorCao, Xuehong
dc.contributor.authorValencia-Torres, Lourdes
dc.contributor.authorYan, Xiaofeng
dc.contributor.authorSaito, Kenji
dc.contributor.authorWang, Chunmei
dc.contributor.authorYang, Yongjie
dc.contributor.authorHinton Jr., Antentor
dc.contributor.authorZhu, Liangru
dc.contributor.authorShu, Gang
dc.contributor.authorMyers Jr., Martin G.
dc.contributor.authorWu, Qi
dc.contributor.authorTong, Qingchun
dc.contributor.authorHeisler, Lora K.
dc.contributor.authorXu, Yong
dc.date.accessioned2016-08-16T09:05:44Z
dc.date.available2016-08-16T09:05:44Z
dc.date.issued2017-05-01
dc.identifier70041491
dc.identifierccdb1bbb-c28b-4548-9f37-71f61ca3a1ec
dc.identifier84995646353
dc.identifier.citationXu , P , He , Y , Cao , X , Valencia-Torres , L , Yan , X , Saito , K , Wang , C , Yang , Y , Hinton Jr. , A , Zhu , L , Shu , G , Myers Jr. , M G , Wu , Q , Tong , Q , Heisler , L K & Xu , Y 2017 , ' Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice ' , Biological Psychiatry , vol. 81 , no. 9 , pp. 737-747 . https://doi.org/10.1016/j.biopsych.2016.06.005en
dc.identifier.issn0006-3223
dc.identifier.otherORCID: /0000-0002-7731-1419/work/30894566
dc.identifier.urihttp://hdl.handle.net/2164/7343
dc.descriptionAcknowledgments and Disclosures This work was supported by the National Institutes of Health (Grant Nos. R01DK093587 and R01DK101379 [to YX], R01DK092605 to [QT], R01DK078056 [to MM]), the Klarman Family Foundation (to YX), the Naman Family Fund for Basic Research (to YX), Curtis Hankamer Basic Research Fund (to YX), American Diabetes Association (Grant Nos. 7-13-JF-61 [to QW] and 1-15-BS-184 [to QT]), American Heart Association postdoctoral fellowship (to PX), Wellcome Trust (Grant No. WT098012 [to LKH]), and Biotechnology and Biological Sciences Research Council (Grant No. BB/K001418/1 [to LKH]). The anxiety tests (e.g., open-field test, light-dark test, elevated plus maze test) were performed in the Mouse Neurobehavior Core, Baylor College of Medicine, which was supported by National Institutes of Health Grant No. P30HD024064. PX and YH were involved in experimental design and most of the procedures, data acquisition and analyses, and writing the manuscript. XC assisted in the electrophysiological recordings; LV-T assisted in the histology study; XY, KS, CW, YY, AH, LZ, and GS assisted in surgical procedures and production of study mice. MGM, QW, QT, and LKH were involved in study design and writing the manuscript. YX is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The authors report no biomedical financial interests or potential conflicts of interest.en
dc.format.extent11
dc.format.extent6601332
dc.language.isoeng
dc.relation.ispartofBiological Psychiatryen
dc.subjectbinge eatingen
dc.subjectdopamineen
dc.subjectlorcaserinen
dc.subjectreceptoren
dc.subjectneuronen
dc.subjectserotoninen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K001418/1en
dc.subjectWellcome Trusten
dc.subjectWT098012en
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleActivation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Miceen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.description.statusPeer revieweden
dc.identifier.doi10.1016/j.biopsych.2016.06.005


Files in this item

Thumbnail
Name:
1_s2.0_S0006322316324702_main.pdf
Size:
6.295Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record