Show simple item record

Neuronal human BACE1 knock-in induces systemic diabetes in mice

dc.contributor.authorPlucinska, Kaja
dc.contributor.authorDekeryte, Ruta
dc.contributor.authorKoss, David
dc.contributor.authorShearer, Kirsty
dc.contributor.authorMody, Nimesh
dc.contributor.authorWhitfield, Phillip D.
dc.contributor.authorDoherty, Mary K.
dc.contributor.authorMingarelli, Marco
dc.contributor.authorWelch, Andy
dc.contributor.authorRiedel, Gernot
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorPlatt, Bettina
dc.date.accessioned2016-05-30T13:40:03Z
dc.date.available2016-05-30T13:40:03Z
dc.date.issued2016-07
dc.identifier.citationPlucinska , K , Dekeryte , R , Koss , D , Shearer , K , Mody , N , Whitfield , P D , Doherty , M K , Mingarelli , M , Welch , A , Riedel , G , Delibegovic , M & Platt , B 2016 , ' Neuronal human BACE1 knock-in induces systemic diabetes in mice ' , Diabetologia , vol. 59 , no. 7 , pp. 1513-1523 . https://doi.org/10.1007/s00125-016-3960-1en
dc.identifier.issn0012-186X
dc.identifier.otherPURE: 63896262
dc.identifier.otherPURE UUID: 075ba402-0785-4123-bcc8-81afc56f3750
dc.identifier.otherPubMed: 27138913
dc.identifier.otherScopus: 84965020773
dc.identifier.otherORCID: /0000-0002-2215-7952/work/36967446
dc.identifier.otherORCID: /0000-0002-7852-0749/work/76976921
dc.identifier.urihttp://hdl.handle.net/2164/6022
dc.descriptionAcknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R. Simcox, Romex Oilfield Chemicals, for financial support for KP, and acknowledge additional contributions from the Scottish Alzheimer’s Research UK network for the lipidomics work. The College of Life Science and Medicine, University of Aberdeen, sponsored the imaging study. MD was funded by British Heart Foundation and Diabetes UK; NM was funded by a British Heart Foundation Intermediate Fellowship; KS was funded by a European Foundation for the Study of Diabetes/Lilly programme grant; and RD was funded by an Institute of Medical Sciences PhD studentship.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofDiabetologiaen
dc.rights© The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.rightsOpen Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectneuronal BACE1en
dc.subjectglucose homeostasisen
dc.subjectceramideen
dc.subjectER stressen
dc.subject18FDG-PETen
dc.subjectinsulin signallingen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subject.lccRen
dc.titleNeuronal human BACE1 knock-in induces systemic diabetes in miceen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1007/s00125-016-3960-1


Files in this item

Thumbnail
Name:
art_3A10.1007_2Fs00125_016_396 ...
Size:
1.416Mb
Format:
PDF
View/Open
Thumbnail
Name:
Plucinska_et_al_Diabetologia_n ...
Size:
1.416Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record