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Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort

dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorSmith, Andrew H.
dc.contributor.authorGelernter, Joel
dc.contributor.authorKranzler, Henry R.
dc.contributor.authorFarrer, Lindsay A.
dc.contributor.authorHall, Lynsey S.
dc.contributor.authorFernandez-Pujals, Ana M.
dc.contributor.authorMacIntyre, Donald J.
dc.contributor.authorSmith, Blair H.
dc.contributor.authorHocking, Lynne J.
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorHayward, Caroline
dc.contributor.authorThomson, Pippa A.
dc.contributor.authorPorteous, David J.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorMcIntosh, Andrew M.
dc.date.accessioned2016-02-25T13:00:02Z
dc.date.available2016-02-25T13:00:02Z
dc.date.issued2016-03
dc.identifier50841481
dc.identifiercac3ceea-0ea3-4de1-9f05-e1284f60826e
dc.identifier25865819
dc.identifier84959203124
dc.identifier.citationClarke , T-K , Smith , A H , Gelernter , J , Kranzler , H R , Farrer , L A , Hall , L S , Fernandez-Pujals , A M , MacIntyre , D J , Smith , B H , Hocking , L J , Padmanabhan , S , Hayward , C , Thomson , P A , Porteous , D J , Deary , I J & McIntosh , A M 2016 , ' Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort ' , Addiction Biology , vol. 21 , no. 2 , pp. 469-480 . https://doi.org/10.1111/adb.12245en
dc.identifier.issn1355-6215
dc.identifier.urihttp://hdl.handle.net/2164/5551
dc.descriptionAcknowledgements We are grateful to the families who took part in GS:SFHS, the GPs and Scottish School of Primary Care for their help in recruiting them, and the whole GS team, which includes academic researchers, clinic staff, laboratory technicians, clerical workers, IT staff, statisticians and research managers. Funded by Scottish Government Health Department, Chief Scientist Office. Grant Number: CZD/16/6 National Institutes of Health. Grant Numbers: N01-HG-65403, HHSN268200782096C, RC2 DA028909, R01 DA12690, R01 DA12849, R01 DA18432, R01 AA11330, R01 AA017535, P50 AA12870, MSTP T32GM07205, CTSA 8UL1TR000142 NIH Genes, Environment and Health Initiative [GEI]. Grant Numbers: U01 HG004422, U01HG004438 Gene Environment Association Studies (GENEVA). Grant Number: U01 HG004446 Collaborative Study on the Genetics of Alcoholism. Grant Number: U10 AA008401 Collaborative Genetic Study of Nicotine Dependence. Grant Number: P01 CA089392 Family Study of Cocaine Dependence. Grant Number: R01 DA013423 National Institute on Alcohol Abuse and Alcoholism National Institute on Drug Abuse Dr Mortimer and Theresa Sackler Foundation Biotechnology and Biological Sciences Research Council (BBSRC) Medical Research Council (MRC)en
dc.format.extent12
dc.format.extent370191
dc.language.isoeng
dc.relation.ispartofAddiction Biologyen
dc.subjectalcohol dependenceen
dc.subjectcognitionen
dc.subjectenvironmenten
dc.subjectgeneticsen
dc.subjectpolygenicen
dc.subjectsocial deprivationen
dc.subjectQH301 Biologyen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectMedical Research Council (MRC)en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subject.lccQH301en
dc.titlePolygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohorten
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1111/adb.12245


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