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Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer : cohort study and literature review

dc.contributor.authorImamura, Yu
dc.contributor.authorLochhead, Paul
dc.contributor.authorYamauchi, Mai
dc.contributor.authorKuchiba, Aya
dc.contributor.authorQian, Zhi Rong
dc.contributor.authorLiao, Xiaoyun
dc.contributor.authorNishihara, Reiko
dc.contributor.authorJung, Seungyoun
dc.contributor.authorWu, Kana
dc.contributor.authorNosho, Katsuhiko
dc.contributor.authorWang, Yaoyu E
dc.contributor.authorPeng, Shouyong
dc.contributor.authorBass, Adam J
dc.contributor.authorHaigis, Kevin M
dc.contributor.authorMeyerhardt, Jeffrey A
dc.contributor.authorChan, Andrew T
dc.contributor.authorFuchs, Charles S
dc.contributor.authorOgino, Shuji
dc.date.accessioned2016-02-02T12:44:02Z
dc.date.available2016-02-02T12:44:02Z
dc.date.issued2014-05-31
dc.identifier37956990
dc.identifier8734e7bf-f030-440a-bc54-08996ebd9c42
dc.identifier24885062
dc.identifier84902532849
dc.identifier.citationImamura , Y , Lochhead , P , Yamauchi , M , Kuchiba , A , Qian , Z R , Liao , X , Nishihara , R , Jung , S , Wu , K , Nosho , K , Wang , Y E , Peng , S , Bass , A J , Haigis , K M , Meyerhardt , J A , Chan , A T , Fuchs , C S & Ogino , S 2014 , ' Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer : cohort study and literature review ' , Molecular Cancer , vol. 13 , 135 . https://doi.org/10.1186/1476-4598-13-135en
dc.identifier.issn1476-4598
dc.identifier.urihttp://hdl.handle.net/2164/5480
dc.descriptionAcknowledgments We deeply thank hospitals and pathology departments throughout the U.S. for generously providing us with tissue specimens. In addition, we would like to thank the participants and staff of the Nurses’ Health Study and the Health Professionals Follow-Up Study, for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. This work was supported by U.S. National Institute of Health (NIH) grants [P01 CA87969 to S.E. Hankinson; P01 CA55075 to W.C. Willett; UM1 CA167552 to W.C. Willett; P50 CA127003 to CSF; R01 CA137178 to ATC; and R01 CA151993 to SO]; and by grants from the Bennett Family Fund and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. ATC is a Damon Runyon Clinical Investigator. PL is a Scottish Government Clinical Academic Fellow and was supported by a Harvard University Frank Knox Memorial Fellowship. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent523571
dc.language.isoeng
dc.relation.ispartofMolecular Canceren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectclinical outcomeen
dc.subjectcolon canceren
dc.subjectgenetic changeen
dc.subjectRAFen
dc.subjectRASen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subject.lccRC0254en
dc.titleAnalyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer : cohort study and literature reviewen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.identifier.doi10.1186/1476-4598-13-135


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