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Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke

dc.contributor.authorMair, Grant
dc.contributor.authorvon Kummer, Rüdiger
dc.contributor.authorMorris, Zoe
dc.contributor.authorvon Heijne, Anders
dc.contributor.authorBradey, Nick
dc.contributor.authorCala, Lesley
dc.contributor.authorPeeters, André
dc.contributor.authorFarrall, Andrew J
dc.contributor.authorAdami, Alessandro
dc.contributor.authorPotter, Gillian
dc.contributor.authorCohen, Geoff
dc.contributor.authorSandercock, Peter A. G.
dc.contributor.authorLindley, Richard I.
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorIST-3 Collaborative Group
dc.date.accessioned2016-01-29T11:04:01Z
dc.date.available2016-01-29T11:04:01Z
dc.date.issued2016-01-12
dc.identifier60578943
dc.identifiere7a1e5d1-9a81-4242-8aef-5d6330553921
dc.identifier26658907
dc.identifier84954342168
dc.identifier.citationMair , G , von Kummer , R , Morris , Z , von Heijne , A , Bradey , N , Cala , L , Peeters , A , Farrall , A J , Adami , A , Potter , G , Cohen , G , Sandercock , P A G , Lindley , R I , Wardlaw , J M & IST-3 Collaborative Group 2016 , ' Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke ' , Neurology , vol. 86 , no. 2 , pp. 118-125 . https://doi.org/10.1212/WNL.0000000000002236en
dc.identifier.issn0028-3878
dc.identifier.urihttp://hdl.handle.net/2164/5454
dc.description© 2015 American Academy of Neurology. STUDY FUNDING The startup phase of IST-3 was supported by a grant from the Stroke Association, UK (TSA 04/99). The expansion phase was funded by the Health Foundation UK (2268/1282). The scan reading development was funded by Chest, Heart Stroke Scotland (R100/7). The main phase of the trial is funded by UK Medical Research Council (MRC) (grant numbers G0400069 and EME 09-800-15) and managed by NIHR on behalf of the MRC-NIHR partnership; the Research Council of Norway; Arbetsmarknadens Partners Forsakringsbolag (AFA) Insurances Sweden; the Swedish Heart Lung Fund; The Foundation of Marianne and Marcus Wallenberg, Stockholm County Council; Karolinska Institute Joint ALF-project grants Sweden; the Polish Ministry of Science and Education (grant number 2PO5B10928); the Australian Heart Foundation; Australian National Health and Medical Research Council (NHMRC); the Swiss National Research Foundation; the Swiss Heart Foundation; the Foundation for Health and Cardio-/Neurovascular Research, Basel, Switzerland; the Assessorato alla Sanita, Regione dell'Umbria, Italy; and, Danube University, Krems, Austria. Boehringer-Ingelheim GmbH donated drug and placebo for the 300 patients in the double-blind phase, but thereafter had no role in the trial. The UK Stroke Research Network (SRN study ID 2135) adopted the trial on 1/5/2006, supported the initiation of new UK sites, and in some centers, and, after that date, data collection was undertaken by staff funded by the network or working for associated NHS organizations. IST-3 acknowledges the support of the NIHR Stroke Research Network, NHS Research Scotland (NRS), through the Scottish Stroke Research Network, and the National Institute for Social Care and Health Research Clinical Research Centre (NISCHR CRC). The central imaging work was undertaken at the Brain Imaging Research Centre (www.sbirc.ed.ac.uk), a member of the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) collaboration (www.sinapse.ac.uk), at the Division of Clinical Neurosciences, University of Edinburgh. SINAPSE is funded by the Scottish Funding Council (SFC) and the Chief Scientist Office of the Scottish Executive (CSO). Additional support was received from Chest Heart and Stroke Scotland, DesAcc, University of Edinburgh, Danderyd Hospital R&D Department, Karolinska Institutet, Oslo University Hospital, and the Dalhousie University Internal Medicine Research Fund.en
dc.format.extent8
dc.format.extent475583
dc.language.isoeng
dc.relation.ispartofNeurologyen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectG0400069en
dc.subjectEME 09-800-15en
dc.subjectScottish Funding Councilen
dc.subjectChief Scientist Office (CSO)en
dc.subject.lccRen
dc.titleEffect of alteplase on the CT hyperdense artery sign and outcome after ischemic strokeen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1212/WNL.0000000000002236


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