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Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration

dc.contributor.authorJoyce, Peter I.
dc.contributor.authorFratta, Pietro
dc.contributor.authorLandman, Allison S.
dc.contributor.authorMcgoldrick, Philip
dc.contributor.authorWackerhage, Henning
dc.contributor.authorGroves, Michael
dc.contributor.authorBusam, Bharani Shiva
dc.contributor.authorGalino, Jorge
dc.contributor.authorCorrochano, Silvia
dc.contributor.authorBeskina, Olga A.
dc.contributor.authorEsapa, Christopher
dc.contributor.authorRyder, Edward
dc.contributor.authorCarter, Sarah
dc.contributor.authorStewart, Michelle
dc.contributor.authorCodner, Gemma
dc.contributor.authorHilton, Helen
dc.contributor.authorTeboul, Lydia
dc.contributor.authorTucker, Jennifer
dc.contributor.authorLionikas, Arimantas
dc.contributor.authorEstabel, Jeanne
dc.contributor.authorRamirez-Solis, Ramiro
dc.contributor.authorWhite, Jacqueline K.
dc.contributor.authorBrandner, Sebastian
dc.contributor.authorPlagnol, Vincent
dc.contributor.authorBennet, David L. H.
dc.contributor.authorAbramov, Andrey Y.
dc.contributor.authorGreensmith, Linda
dc.contributor.authorFisher, Elizabeth M. C.
dc.contributor.authorAcevedo-Arozena, Abraham
dc.date.accessioned2016-01-29T10:49:01Z
dc.date.available2016-01-29T10:49:01Z
dc.date.issued2016-01-15
dc.identifier60533342
dc.identifierca958ef3-b301-4c81-b714-ce6957a44b2c
dc.identifier26604141
dc.identifier84960808511
dc.identifier.citationJoyce , P I , Fratta , P , Landman , A S , Mcgoldrick , P , Wackerhage , H , Groves , M , Busam , B S , Galino , J , Corrochano , S , Beskina , O A , Esapa , C , Ryder , E , Carter , S , Stewart , M , Codner , G , Hilton , H , Teboul , L , Tucker , J , Lionikas , A , Estabel , J , Ramirez-Solis , R , White , J K , Brandner , S , Plagnol , V , Bennet , D L H , Abramov , A Y , Greensmith , L , Fisher , E M C & Acevedo-Arozena , A 2016 , ' Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration ' , Human Molecular Genetics , vol. 25 , no. 2 , pp. 291-307 . https://doi.org/10.1093/hmg/ddv471en
dc.identifier.issn0964-6906
dc.identifier.otherORCID: /0000-0002-0052-6171/work/76975835
dc.identifier.urihttp://hdl.handle.net/2164/5452
dc.descriptionAcknowledgements We are indebted to Jim Humphries, JennyCorrigan, LizDarley, Elizabeth Joynson, Natalie Walters, Sara Wells and the whole necropsy, histology, genotyping and MLC ward 6 teams at MRC Harwell for excellent technical assistance. We thank the staff of the WTSI Illumina Bespoke Team for the RNA-seq data, the Sanger Mouse Genetics Project for the initial mouse characterization and Dr David Adams for critical reading of the manuscript. We also thank KOMP for the mouse embryonic stem cells carrying the knockout first promoter-less allele (tm1a(KOMP)Wtsi) within Zfp016. Conflict of Interest statement. None declared. Funding This work was funded by the UK Medical Research Council (MRC) to A.A.-A. and a Motor Neurone Disease Association (MNDA) project grant to A.A.-A. and EMCF. D.L.H.B. is a Wellcome Trust Senior Clinical Scientist Fellow and P.F. is a MRC/MNDA Lady Edith Wolfson Clinician Scientist Fellow. Funding to pay the Open Access publication charges for this article was provided by the MRC grant number: MC_UP_A390_1106.en
dc.format.extent17
dc.format.extent1906420
dc.language.isoeng
dc.relation.ispartofHuman Molecular Geneticsen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UP_A390_1106en
dc.subject.lccRen
dc.titleDeficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegenerationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1093/hmg/ddv471


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