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Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

dc.contributor.authorMatula, Kasia
dc.contributor.authorCollie-Duguid, Elaina
dc.contributor.authorMurray, Graeme
dc.contributor.authorParikh, Khyati
dc.contributor.authorGrabsch, H I
dc.contributor.authorTan, Patrick
dc.contributor.authorLalwani, Salina
dc.contributor.authorGarau, Roberta
dc.contributor.authorOng, Yuhan
dc.contributor.authorBain, Gillian
dc.contributor.authorDahle-Smith, Asa
dc.contributor.authorUrquhart, Gordon
dc.contributor.authorBielawski, Jacek
dc.contributor.authorFinnegan, Michael
dc.contributor.authorPetty, Russell
dc.date.accessioned2015-10-27T11:50:02Z
dc.date.available2015-10-27T11:50:02Z
dc.date.issued2015-10
dc.identifier58136708
dc.identifierf5f153f8-ea24-451e-97d2-9d4be5d06ef7
dc.identifier84944688789
dc.identifier.citationMatula , K , Collie-Duguid , E , Murray , G , Parikh , K , Grabsch , H I , Tan , P , Lalwani , S , Garau , R , Ong , Y , Bain , G , Dahle-Smith , A , Urquhart , G , Bielawski , J , Finnegan , M & Petty , R 2015 , ' Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer ' , BMC Cancer , vol. 15 , 762 . https://doi.org/10.1186/s12885-015-1718-7en
dc.identifier.issn1471-2407
dc.identifier.otherORCID: /0000-0003-3981-2420/work/76973557
dc.identifier.urihttp://hdl.handle.net/2164/5116
dc.descriptionOpen Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Acknowledgements This work was funded by GASTROCAN (Grampian Gastroesophageal Cancer Research Fund), National Health Service Grampian Research and Development and the Jackie Strachan Research Fellowship. We would like to acknowledge the assistance of the NHS Grampian Bio-repository and are also are grateful to Nicky Fyfe and Dr Keith Stewart for assistance with immunohistochemistry. Financial Support This work was funded by grants to RP from GASTROCAN (Grampian Gastroesophageal Cancer Research Fund), National Health Service Grampian Research and Development and the Jackie Strachan Research Fellowship.en
dc.format.extent14
dc.format.extent3744227
dc.language.isoeng
dc.relation.ispartofBMC Canceren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectgastroesophageal canceren
dc.subjectchemoresistanceen
dc.subjectsphingosine-1-phosphateen
dc.subjectsphingosine kinase 1en
dc.subjectR Medicineen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleRegulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal canceren
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.University of Aberdeenen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1186/s12885-015-1718-7


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