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Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies

dc.contributor.authorWalker, Louise A
dc.contributor.authorLee, Keunsook
dc.contributor.authorMunro, Carol A
dc.contributor.authorGow, Neil A R
dc.date.accessioned2015-09-23T09:03:02Z
dc.date.available2015-09-23T09:03:02Z
dc.date.issued2015-10
dc.identifier.citationWalker , L A , Lee , K , Munro , C A & Gow , N A R 2015 , ' Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies ' , Antimicrobial Agents and Chemotherapy , vol. 59 , no. 10 , pp. 5932-5941 . https://doi.org/10.1128/AAC.00862-15en
dc.identifier.issn0066-4804
dc.identifier.otherPURE: 53972144
dc.identifier.otherPURE UUID: 8a0fae7e-fea4-4c01-94d9-845a7fd61da1
dc.identifier.otherPubMed: 26169407
dc.identifier.otherPubMed: 26169407
dc.identifier.otherScopus: 84942291912
dc.identifier.otherORCID: /0000-0002-2236-8776/work/100346473
dc.identifier.urihttp://hdl.handle.net/2164/4935
dc.descriptionDate of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D. studentships for L.A.W. and K.K.L. We also acknowledge research grants from the Wellcome Trust (080088, 086827, 075470, 099215, and 097377) and the British Society for Antimicrobial Chemotherapy.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/en
dc.subjectchitinen
dc.subjectdrug resistanceen
dc.subjectechinocandinen
dc.subjectfungal cell wallen
dc.subjectsignal transductionen
dc.subjectQR Microbiologyen
dc.subject.lccQRen
dc.titleCaspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcoloniesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1128/AAC.00862-15


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