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Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

dc.contributor.authorMelis, V
dc.contributor.authorZabke, C
dc.contributor.authorStamer, K
dc.contributor.authorMagbagbeolu, M
dc.contributor.authorSchwab, K
dc.contributor.authorMarshall, P.
dc.contributor.authorWeh, R. W.
dc.contributor.authorBachmann, S
dc.contributor.authorDeiana, S
dc.contributor.authorMoreau, P H
dc.contributor.authorDavidson, K
dc.contributor.authorHarrington, K A
dc.contributor.authorRickard, J E
dc.contributor.authorHorsley, D
dc.contributor.authorGarman, R
dc.contributor.authorMazurkiewicz, M
dc.contributor.authorNiewiadomska, G
dc.contributor.authorWischik, C M
dc.contributor.authorHarrington, C R
dc.contributor.authorRiedel, G
dc.contributor.authorTheuring, F.
dc.date.accessioned2015-05-28T13:46:08Z
dc.date.available2015-05-28T13:46:08Z
dc.date.issued2015-06
dc.identifier51356929
dc.identifier8c8e622f-8707-4795-a85c-be5b6f0f6eb6
dc.identifier84928386659
dc.identifier.citationMelis , V , Zabke , C , Stamer , K , Magbagbeolu , M , Schwab , K , Marshall , P , Weh , R W , Bachmann , S , Deiana , S , Moreau , P H , Davidson , K , Harrington , K A , Rickard , J E , Horsley , D , Garman , R , Mazurkiewicz , M , Niewiadomska , G , Wischik , C M , Harrington , C R , Riedel , G & Theuring , F 2015 , ' Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration ' , Cellular and Molecular Life Sciences , vol. 72 , no. 11 , pp. 2199-2222 . https://doi.org/10.1007/s00018-014-1804-zen
dc.identifier.issn1420-682X
dc.identifier.otherORCID: /0000-0001-7063-7136/work/96652489
dc.identifier.urihttp://hdl.handle.net/2164/4567
dc.descriptionOpen Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Acknowledgments From the Berlin Laboratory, we thank Ingo Voigt for performing the injections of the two constructs into the oocytes, Bettina Seelhorst for her extensive technical assistance, Anna Thoma for taking specific care of the animals, and John Horn, Charite Core Facility for electron microscopy for performing expert analyses in ultra-cryosections with immunogold technique. Expert comments on the manuscript from Silke Frahm-Barske (Berlin) are also acknowledged. Special thanks to Bob Switzer at NeuroScience Associates Inc. for embedding, sectioning and staining mouse brains. This work was funded by TauRx Therapeutics, Singapore. C.R.H. and C.M.W. declare that they are officers in TauRx Therapeutics Ltd.en
dc.format.extent24
dc.format.extent11254039
dc.language.isoeng
dc.relation.ispartofCellular and Molecular Life Sciencesen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectTau proteinen
dc.subjecttransgenic miceen
dc.subjectP301Len
dc.subjecttruncated cDNA Tau296-390en
dc.subjectmotor impairmenten
dc.subjectspatial cognitionen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleDifferent pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degenerationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1007/s00018-014-1804-z


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