Structural insights and biomedical potential of IgNAR scaffolds from sharks

Zielonka, Stefan; Empting, Martin; Grzeschik, Julius; Könning, Doreen; Barelle, Caroline; Kolmar, Harald

dc.contributor.author	Zielonka, Stefan
dc.contributor.author	Empting, Martin
dc.contributor.author	Grzeschik, Julius
dc.contributor.author	Könning, Doreen
dc.contributor.author	Barelle, Caroline
dc.contributor.author	Kolmar, Harald
dc.date.accessioned	2015-01-26T11:10:01Z
dc.date.available	2015-01-26T11:10:01Z
dc.date.issued	2015
dc.identifier	45563819
dc.identifier	eb3aeda3-3df1-44ff-8009-ac2996e4b1ad
dc.identifier	25523873
dc.identifier	84921385703
dc.identifier.citation	Zielonka , S , Empting , M , Grzeschik , J , Könning , D , Barelle , C & Kolmar , H 2015 , ' Structural insights and biomedical potential of IgNAR scaffolds from sharks ' , mAbs , vol. 7 , no. 1 , pp. 15-25 . https://doi.org/10.4161/19420862.2015.989032	en
dc.identifier.issn	1942-0862
dc.identifier.uri	http://hdl.handle.net/2164/4199
dc.format.extent	11
dc.format.extent	881843
dc.language.iso	eng
dc.relation.ispartof	mAbs	en
dc.subject	antibody technology	en
dc.subject	biologic therapeutic	en
dc.subject	heavy chain antibody	en
dc.subject	IgNAR	en
dc.subject	shark	en
dc.subject	single chain binding domain	en
dc.subject	CDR	en
dc.subject	complementary-determining region	en
dc.subject	HV	en
dc.subject	hypervariable region	en
dc.subject	immunoglobin new antigen receptor	en
dc.subject	IgNAR V domain	en
dc.subject	variable domain of IgNAR	en
dc.subject	mAbs	en
dc.subject	monoclonal antibodies	en
dc.subject	scFv	en
dc.subject	single chain variable fragment	en
dc.subject	VL	en
dc.subject	variable domain of the light chain	en
dc.subject	VH	en
dc.subject	variable domain of the heavy chain	en
dc.subject	VHH	en
dc.subject	variable domain of camelid heavy chain antibodies	en
dc.subject	vNAR	en
dc.subject	QH301 Biology	en
dc.subject.lcc	QH301	en
dc.title	Structural insights and biomedical potential of IgNAR scaffolds from sharks	en
dc.type	Journal article	en
dc.contributor.institution	University of Aberdeen.Medical Sciences	en
dc.description.status	Peer reviewed	en
dc.identifier.doi	10.4161/19420862.2015.989032

Files in this item

Name:: 19420862.2015.pdf
Size:: 861.1Kb
Format:: PDF

View/Open

This item appears in the following Collection(s)

All research

Show simple item record


	The Sir Duncan Rice Library University of Aberdeen Bedford Road Aberdeen AB24 3AA Tel: +44 (0)1224 273330 Email: library@abdn.ac.uk

Structural insights and biomedical potential of IgNAR scaffolds from sharks

Files in this item

This item appears in the following Collection(s)

Related items

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development ﻿

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand ﻿

Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents ﻿

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand

Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents