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Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

dc.contributor.authorWagener, Jeanette
dc.contributor.authorMalireddi, R K Subbarao
dc.contributor.authorLenardon, Megan D
dc.contributor.authorKöberle, Martin
dc.contributor.authorVautier, Simon
dc.contributor.authorMacCallum, Donna M
dc.contributor.authorBiedermann, Tilo
dc.contributor.authorSchaller, Martin
dc.contributor.authorNetea, Mihai G
dc.contributor.authorKanneganti, Thirumala-Devi
dc.contributor.authorBrown, Gordon D
dc.contributor.authorBrown, Alistair J P
dc.contributor.authorGow, Neil A R
dc.date.accessioned2014-09-08T11:32:03Z
dc.date.available2014-09-08T11:32:03Z
dc.date.issued2014-04-10
dc.identifier34480222
dc.identifier576791a8-d8dc-4bc6-8116-445b807e79e8
dc.identifier24722226
dc.identifier84901313667
dc.identifier.citationWagener , J , Malireddi , R K S , Lenardon , M D , Köberle , M , Vautier , S , MacCallum , D M , Biedermann , T , Schaller , M , Netea , M G , Kanneganti , T-D , Brown , G D , Brown , A J P & Gow , N A R 2014 , ' Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation ' , PLoS Pathogens , vol. 10 , no. 4 , e1004050 . https://doi.org/10.1371/journal.ppat.1004050en
dc.identifier.issn1553-7366
dc.identifier.otherORCID: /0000-0003-4833-0378/work/47631072
dc.identifier.otherORCID: /0000-0002-7227-4348/work/40417674
dc.identifier.urihttp://hdl.handle.net/2164/3463
dc.descriptionFunding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported by a Vici grant of the Netherlands Organisation for Scientific Research. AJPB and DMM were funded by STRIFE, ERC-2009-AdG-249793 and AJPB additionally by FINSysB, PITN-GA-2008-214004 and the BBSRC [BB/F00513X/1]. MDL was supported by the MRC (MR/J008230/1). GDB and SV were funded by the Wellcome Trust (086558) and TB and MK were funded by the Deutsche Forschungsgemeinschaft (Bi 696/3-1; Bi 696/5-2; Bi 696/10-1). MS was supported by the Deutsche Forschungsgemeinschaft (Sch 897/1-3) and the National Institute of Dental and Craniofacial Research (R01 DE017514-01). TDK and RKSM were funded by the National Institute of Health (AR056296, AI101935) and the American Lebanese Syrian Associated Charities (ALSAC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent15
dc.format.extent1957781
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectChitinen
dc.subjectSecretionen
dc.subjectCandida albicansen
dc.subjectCytokinesen
dc.subjectMacrophagesen
dc.subjectCell wallsen
dc.subjectInflammationen
dc.subjectFungal phatogensen
dc.subjectQR Microbiologyen
dc.subjectWellcome Trusten
dc.subject086827en
dc.subject080088en
dc.subject075470en
dc.subject097377en
dc.subject086558en
dc.subjectEuropean Commissionen
dc.subjectFP7/2007 2013en
dc.subjectHEALTH-2010-260338en
dc.subjectEuropean Research Councilen
dc.subjectERC-2009-AdG-249793en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/F00513X/1en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/J008230/1en
dc.subjectSupplementary Dataen
dc.subject.lccQRen
dc.titleFungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.identifier.doi10.1371/journal.ppat.1004050


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