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Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

dc.contributor.authorWishart, Thomas M
dc.contributor.authorMutsaers, Chantal A
dc.contributor.authorRiessland, Markus
dc.contributor.authorReimer, Michell M
dc.contributor.authorHunter, Gillian
dc.contributor.authorHannam, Marie L
dc.contributor.authorEaton, Samantha L
dc.contributor.authorFuller, Heidi R
dc.contributor.authorRoche, Sarah L
dc.contributor.authorSomers, Eilidh
dc.contributor.authorMorse, Robert
dc.contributor.authorYoung, Philip J
dc.contributor.authorLamont, Douglas J
dc.contributor.authorHammerschmidt, Matthias
dc.contributor.authorJoshi, Anagha
dc.contributor.authorHohenstein, Peter
dc.contributor.authorMorris, Glenn E
dc.contributor.authorParson, Simon H
dc.contributor.authorSkehel, Paul A
dc.contributor.authorBecker, Thomas
dc.contributor.authorRobinson, Iain M
dc.contributor.authorBecker, Catherina G
dc.contributor.authorWirth, Brunhilde
dc.contributor.authorGillingwater, Thomas H
dc.date.accessioned2014-09-02T12:47:02Z
dc.date.available2014-09-02T12:47:02Z
dc.date.issued2014-04-01
dc.identifier40107326
dc.identifier38682f63-e67a-46b5-93fd-816501d28239
dc.identifier000333723400040
dc.identifier84897548490
dc.identifier.citationWishart , T M , Mutsaers , C A , Riessland , M , Reimer , M M , Hunter , G , Hannam , M L , Eaton , S L , Fuller , H R , Roche , S L , Somers , E , Morse , R , Young , P J , Lamont , D J , Hammerschmidt , M , Joshi , A , Hohenstein , P , Morris , G E , Parson , S H , Skehel , P A , Becker , T , Robinson , I M , Becker , C G , Wirth , B & Gillingwater , T H 2014 , ' Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy ' , The Journal of Clinical Investigation , vol. 124 , no. 4 , pp. 1821-1834 . https://doi.org/10.1172/JCI71318en
dc.identifier.issn0021-9738
dc.identifier.otherORCID: /0000-0002-8848-8738/work/82379640
dc.identifier.urihttp://hdl.handle.net/2164/3424
dc.descriptionAcknowledgements The authors are grateful to Nils Lindstrom and members of the Gillingwater laboratory for advice and assistance with this study and helpful comments on the manuscript; Neil Cashman for the NSC-34 cell line; and Ji-Long Liu for the DrosophilasmnA and smnB lines. This work was supported by grants from the SMA Trust (to T.H. Gillingwater, P.J. Young, and R. Morse), BDF Newlife (to T.H. Gillingwater and S.H. Parson), the Anatomical Society (to T.H. Gillingwater and S.H. Parson), the Muscular Dystrophy Campaign (to T.H. Gillingwater), the Jennifer Trust for Spinal Muscular Atrophy (to H.R. Fuller), the Muscular Dystrophy Association (to G.E. Morris), the Vandervell Foundation (to P.J. Young), the Medical Research Council (GO82208 to I.M. Robinson), Roslin Institute Strategic Grant funding from the BBSRC (to T.M. Wishart), the BBSRC (to C.G. Becker), the Deutsche Forschungsgemeinschaft and EU FP7/2007-2013 (grant no. 2012-305121, NeurOmics, to B. Wirth), the Center for Molecular Medicine Cologne (to B. Wirth and M. Hammerschmidt), and SMA Europe (to M.M. Reissland). We would also like to acknowledge financial support to the Gillingwater lab generated through donations to the SMASHSMA campaign.en
dc.format.extent14
dc.format.extent4503859
dc.language.isoeng
dc.relation.ispartofThe Journal of Clinical Investigationen
dc.subjectsurvival-motor-neuronen
dc.subjectmouse modelen
dc.subjectSMN proteinen
dc.subjectneuromuscular-junctionen
dc.subjectcircuit functionen
dc.subjectdefectsen
dc.subjectgeneen
dc.subjectcellsen
dc.subjectdrosophilaen
dc.subjectpathologyen
dc.subjectR Medicineen
dc.subjectQH301 Biologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectGO82208en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectEuropean Commissionen
dc.subjectFP7/2007-2013en
dc.subject2012-305121en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.subject.lccQH301en
dc.titleDysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.description.statusPeer revieweden
dc.identifier.doi10.1172/JCI71318


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