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Melatonin as a potential therapy for sepsis : a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis

dc.contributor.authorGalley, Helen F
dc.contributor.authorLowes, Damon A
dc.contributor.authorAllen, Lee
dc.contributor.authorCameron, Gary
dc.contributor.authorAucott, Lorna S
dc.contributor.authorWebster, Nigel R
dc.date.accessioned2014-05-02T10:02:01Z
dc.date.available2014-05-02T10:02:01Z
dc.date.issued2014-05
dc.identifier.citationGalley , H F , Lowes , D A , Allen , L , Cameron , G , Aucott , L S & Webster , N R 2014 , ' Melatonin as a potential therapy for sepsis : a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis ' , Journal of Pineal Research , vol. 56 , no. 4 , pp. 427-438 . https://doi.org/10.1111/jpi.12134en
dc.identifier.issn0742-3098
dc.identifier.otherPURE: 32906263
dc.identifier.otherPURE UUID: b7712bc6-1c79-4f32-9c6a-72aac402fd93
dc.identifier.otherPubMed: 24650045
dc.identifier.otherScopus: 84899429649
dc.identifier.otherORCID: /0000-0001-6277-7972/work/84132258
dc.identifier.urihttp://hdl.handle.net/2164/3237
dc.descriptionThis article is protected by copyright. All rights reserved. This study was funded by the Chief Scientist Office, NHS Scotland. We would like to thank all the volunteers who gave up their time and blood to take part in the study and the data monitoring committee and staff of the intensive care unit for their support. In addition, thanks to Dr Malachy Columb for performing Page's trend test for us and to Annette Fearnley at Nu-Pharm Ltd for her advice.en
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofJournal of Pineal Researchen
dc.rightsCC-BY-NC https://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectsepsisen
dc.subjectmelatoninen
dc.subject6-hydroxymelatoninen
dc.subjectphase 1 clinical trialen
dc.subjectcytokinesen
dc.subjectR Medicineen
dc.subjectChief Scientist Office (CSO)en
dc.subject.lccRen
dc.titleMelatonin as a potential therapy for sepsis : a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1111/jpi.12134
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84897347874&partnerID=8YFLogxKen


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