University of Aberdeen

AURA - Aberdeen University Research Archive

View Item 
  •   AURA Home
  • 5 - All Research
  • All research
  • View Item
  •   AURA Home
  • 5 - All Research
  • All research
  • View Item
  •   AURA Home
  • 5 - All Research
  • All research
  • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Minimally invasive therapies for the treatment of benign prostatic enlargement : systematic review of randomised controlled trials

      View/Open
      Lourenco2008(minimally).pdf (382.3Kb)
      Publication date
      09/10/2008
      Author
      Lourenco, Tania
      Pickard, Robert
      Vale, Luke David
      Grant, Adrian Maxwell
      Fraser, Cynthia Mary
      MacLennan, Graeme Stewart
      N'Dow, James Michael Olu
      Metadata
      Show full item record
      Abstract
      Objective: To compare the effectiveness and risk profile of minimally invasive interventions against the current standard of transurethral resection of the prostate. Design Systematic review and meta-analysis of randomised controlled trials. Data sources Electronic and paper records up to March 2006. Review methods: We searched for all relevant randomised controlled trials. Two reviewers independently extracted data and assessed quality. Meta-analyses of prespecified outcomes were performed with fixed and random effects models and reported using relative risks or weighted mean difference. Results 3794 abstracts were identified; 22 randomised controlled trials met the inclusion criteria. These provided data on 2434 participants. The studies evaluated were of moderate to poor quality with small sample sizes. Minimally invasive interventions were less effective than transurethral resection of the prostate in terms of improvement in symptom scores and increase in urine flow rate, with most comparisons showing significance despite wide confidence intervals. Rates of second operation were significantly higher for minimally invasive treatments. The risk profile of minimally invasive interventions was better than that of transurethral resection, with fewer adverse events. The results, however, showed significant heterogeneity. Conclusion: Which minimally invasive intervention is the most promising remains unclear. Their place in the management of benign prostate enlargement will continue to remain controversial until well designed and well reported randomised controlled trials following CONSORT guidelines prove they are superior and more cost effective than drug treatment or that strategies of sequential surgical treatments are preferred by patients and are more cost effective than the more invasive but more effective tissue ablative interventions such as transurethral resection.
      Citation
      Lorenco, T., Pickard, R., Vale, L., Grant, A., Fraser, C., MacLennan, G., and N'Dow, J., (2008) Minimally invasive therapies for the treatment of benign prostatic enlargement : systematic review of randomised controlled trials. British Medical Journal, 337, pp. 1662-1670.
      URI
      http://hdl.handle.net/2164/262
      DOI
      http://dx.doi.org/10.1136/bmj.a1662
      Collections
      • All research

      Browse

      All of AURACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
      Top of Page
      • AURA Home
      • Accessibility
      • PURE
      • Digital Resources
      • Library, Special Collections & Museums
      • Take-Down Notice
      • Send Feedback
      • Contact Us
         
       
      Library, Special Collections and Museums logo
      The Sir Duncan Rice Library
      University of Aberdeen
      Bedford Road
      Aberdeen
      AB24 3AA

      Tel: +44 (0)1224 273330
      Email: library@abdn.ac.uk
       
         

      Share and keep up to date

      FacebookTwitterWordpress

      • AURA Home
      • Accessibility
      • PURE
      • Digital Resources
      • Library, Special Collections & Museums
      • Take-Down Notice
      • Send Feedback
      • Contact Us