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dc.contributor.authorLourenco, Taniaen
dc.contributor.authorMurray, Alison Catherineen
dc.contributor.authorGrant, Adrian Maxwellen
dc.contributor.authorMcKinley, Aileen Joyceen
dc.contributor.authorKrukowski, Zygmunt H.en
dc.contributor.authorVale, Luke Daviden
dc.date.accessioned2008-05-22T13:14:43Z
dc.date.available2008-05-22T13:14:43Z
dc.date.issued2008
dc.identifier.citationLourenco, T., Murray, A., Grant, A., McKinley, A., Krukowski, Z., and Vale, L. (2008) Laparoscopic surgery for colorectal cancer : safe and effective? - a systematic review. Surgical Endoscopy [Online], 22(5), pp. 1146-1160. Available from: http://www.springerlink.com/content/jw235m3452727g23 [Accessed 22 May 2008]en
dc.identifier.issn1432-2218
dc.identifier.otherPURE: 198942en
dc.identifier.urihttp://hdl.handle.net/2164/203
dc.description.abstractObjective To determine the clinical effectiveness of laparoscopic and laparoscopically assisted surgery in comparison with open surgery for the treatment of colorectal cancer. Background Open resection is the standard method for surgical removal of primary colorectal tumours. However, there is significant morbidity associated with this procedure. Laparoscopic resection (LR) is technically more difficult but may overcome problems associated with open resections (OR). Methods Systematic review and meta-analysis of short- and long-term data from randomised controlled trials (RCTs) comparing LS with OR. Results Highly sensitive searches of nine databases identified 19 primary RCTs describing data from over 4,500 participants. Length of hospital stay is shorter, blood loss and pain are less, and return to usual activities is likely to be faster after LR than after OR, but duration of operation is longer. Lymph node retrieval, completeness of resection and quality of life do not appear to differ. No statistically significant differences were observed in rates of anastomotic leakage, abdominal wound breakdown, incisional hernia, wound and urinary tract infections, operative and 30-day mortality, and recurrences, nor in overall and disease-free survival up to three years. Conclusions LR is associated with a quicker recovery in terms of return to usual activities and length of hospital stay with no evidence of a difference in complications or long-term outcomes in comparison to OR, up to three years postoperatively.en
dc.description.sponsorshipThis study was supported by the NHS R&D HTA programme. The Health Services Research Unit and the Health Economics Research Unit are funded by the Chief Scientist Office of the Scottish Executive Health Department.en
dc.format.extent6897347 bytes
dc.format.extent14 p.en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherSpringeren
dc.rightsThe original publication is available at www.springerlink.comen
dc.subjectColorectal Neoplasmsen
dc.subjectLaparoscopyen
dc.subjectSafetyen
dc.subjectSystematic reviewen
dc.subjectMeta-analysisen
dc.subject.lccRC Internal medicineen
dc.titleLaparoscopic surgery for colorectal cancer : safe and effective? - a systematic reviewen
dc.typeJournal Articleen
dc.typeTexten
dc.contributor.institutionUniversity of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.description.versionAuthor versionen
dc.identifier.doihttp://dx.doi.org/10.1007/s00464-007-9686-x


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