Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
dc.contributor.author | Bergamaschi, Laura | |
dc.contributor.author | Mescia, Federica | |
dc.contributor.author | Turner, Lorinda | |
dc.contributor.author | Hanson, Aimee L. | |
dc.contributor.author | Kotagiri, Prasanti | |
dc.contributor.author | Dunmore, Benjamin J. | |
dc.contributor.author | Ruffieux, Hélène | |
dc.contributor.author | Sa, Aloka De | |
dc.contributor.author | Huhn, Oisín | |
dc.contributor.author | Morgan, Michael D. | |
dc.contributor.author | Gerber, Pehuén Pereyra | |
dc.contributor.author | Wills, Mark R. | |
dc.contributor.author | Baker, Stephen | |
dc.contributor.author | Calero-Nieto, Fernando J. | |
dc.contributor.author | Doffinger, Rainer | |
dc.contributor.author | Dougan, Gordon | |
dc.contributor.author | Elmer, Anne | |
dc.contributor.author | Goodfellow, Ian G. | |
dc.contributor.author | Gupta, Ravindra K. | |
dc.contributor.author | Hosmillo, Myra | |
dc.contributor.author | Hunter, Kelvin | |
dc.contributor.author | Kingston, Nathalie | |
dc.contributor.author | Lehner, Paul J. | |
dc.contributor.author | Matheson, Nicholas J. | |
dc.contributor.author | Nicholson, Jeremy K. | |
dc.contributor.author | Petrunkina, Anna M. | |
dc.contributor.author | Richardson, Sylvia | |
dc.contributor.author | Saunders, Caroline | |
dc.contributor.author | Thaventhiran, James E.D. | |
dc.contributor.author | Toonen, Erik J.M. | |
dc.contributor.author | Weekes, Michael P. | |
dc.contributor.author | Göttgens, Berthold | |
dc.contributor.author | Toshner, Mark | |
dc.contributor.author | Hess, Christoph | |
dc.contributor.author | Bradley, John R. | |
dc.contributor.author | Lyons, Paul A. | |
dc.contributor.author | Smith, Kenneth G.C. | |
dc.contributor.author | Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration | |
dc.date.accessioned | 2024-04-11T23:10:54Z | |
dc.date.available | 2024-04-11T23:10:54Z | |
dc.date.issued | 2021-06-08 | |
dc.identifier | 221553977 | |
dc.identifier | e615dd19-dc0d-4c4e-b14b-59034945f403 | |
dc.identifier.citation | Bergamaschi , L , Mescia , F , Turner , L , Hanson , A L , Kotagiri , P , Dunmore , B J , Ruffieux , H , Sa , A D , Huhn , O , Morgan , M D , Gerber , P P , Wills , M R , Baker , S , Calero-Nieto , F J , Doffinger , R , Dougan , G , Elmer , A , Goodfellow , I G , Gupta , R K , Hosmillo , M , Hunter , K , Kingston , N , Lehner , P J , Matheson , N J , Nicholson , J K , Petrunkina , A M , Richardson , S , Saunders , C , Thaventhiran , J E D , Toonen , E J M , Weekes , M P , Göttgens , B , Toshner , M , Hess , C , Bradley , J R , Lyons , P A , Smith , K G C & Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration 2021 , ' Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease ' , Immunity , vol. 54 , no. 6 , pp. 1257-1275.e8 . https://doi.org/10.1016/j.immuni.2021.05.010 | en |
dc.identifier.issn | 1074-7613 | |
dc.identifier.other | ORCID: /0000-0003-0757-0711/work/94584961 | |
dc.identifier.uri | http://aura-test.abdn.ac.uk/handle/2164/20265 | |
dc.description | Acknowledgements We thank all the patients and health care workers who consented to take part in this study. We are grateful to CVC Capital Partners, the Evelyn Trust (20/75), Addenbrooke's Charitable Trust, Cambridge University Hospitals (12/20A), the NIHR Cambridge Biomedical Research Centre, and the UKRI/NIHR through the UK Coronavirus Immunology Consortium (UK-CIC) for their financial support. Further support: K.G.C.S.: Wellcome Investigator Award (200871/Z/16/Z); M.P.W.: Wellcome Senior Clinical Research Fellowship (108070/Z/15/Z); C.H.: Wellcome COVID-19 Rapid Response DCF and the Fondation Botnar; N.M.: MRC (CSF MR/P008801/1), NHSBT (WPA15-02), and Addenbrooke's Charitable Trust, (grant ref. to 900239 NJM); I.G.G.: Wellcome Senior Fellowship and Wellcome grant (Ref: 207498/Z/17/Z); P.J.L.: Wellcome Trust Principal Research Fellowship (084957/Z/08/Z) and MRC (MR/V011561/1); J.K.N.: The Spinnaker Healthcare Research Trust and the McCusker Foundation as part of Australian National Phenome Centre. P.K. is the recipient of a Jacquot Research Entry Scholarship of the Royal Australasian College of Physicians Foundation. We would like to thank the NIHR Cambridge Clinical Research Facility outreach team for enrollment of patients; the NIHR Cambridge Biomedical Research Centre Cell Phenotyping Hub and the CRUK Cambridge Institute flow cytometry core facility for flow and mass cytometry; and the Cambridge NIHR BRC Stratified Medicine Core Laboratory NGS Hub (supported by an MRC Clinical Infrastructure Award) for RNA sequencing. | en |
dc.format.extent | 28 | |
dc.format.extent | 4408947 | |
dc.language.iso | eng | |
dc.relation.ispartof | Immunity | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject | SARS-CoV-2 | en |
dc.subject | COVID-19 | en |
dc.subject | bystander CD8+ T cell | en |
dc.subject | recovery | en |
dc.subject | immune pathology | en |
dc.subject | systemic inflammation | en |
dc.subject | complement | en |
dc.subject | TNF-α | en |
dc.subject | interferon | en |
dc.subject | R Medicine | en |
dc.subject | QR180 Immunology | en |
dc.subject | Immunology and Allergy | en |
dc.subject | Cell Biology | en |
dc.subject | Infectious Diseases | en |
dc.subject | Biochemistry | en |
dc.subject | National Institute for Health Research (NIHR) | en |
dc.subject | UK Research and Innovation (UKRI) | en |
dc.subject | Wellcome Trust | en |
dc.subject | 200871/Z/16/Z | en |
dc.subject | 108070/Z/15/Z | en |
dc.subject | 207498/Z/17/Z | en |
dc.subject | 084957/Z/08/Z | en |
dc.subject | Medical Research Council (MRC) | en |
dc.subject | CSF MR/P008801/1 | en |
dc.subject | MR/V011561/1 | en |
dc.subject | Other | en |
dc.subject | WPA15-02 | en |
dc.subject | 900239 | en |
dc.subject | Supplementary Data | en |
dc.subject | https://www.covid19cellatlas.org/patient/citiid/ | en |
dc.subject | EGAS00001005332 | en |
dc.subject | FR-FCM-Z3XQ | en |
dc.subject | FR-FCM-Z3SR | en |
dc.subject | FR-FCM-Z3ST | en |
dc.subject | FR-FCM-Z3SS | en |
dc.subject | E-MTAB-10026 | en |
dc.subject.lcc | R | en |
dc.subject.lcc | QR180 | en |
dc.title | Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Institute of Medical Sciences | en |
dc.description.status | Peer reviewed | en |
dc.identifier.doi | 10.1016/j.immuni.2021.05.010 | |
dc.identifier.url | https://doi.org/10.1016/j.immuni.2021.05.010 | en |
dc.identifier.url | https://europepmc.org/article/PMC/PMC8125900 | en |
dc.identifier.vol | 54 | en |
dc.identifier.iss | 6 | en |