dc.contributor.author | Thompson, Dawn | |
dc.contributor.author | Mahmood, Shehroz | |
dc.contributor.author | Morrice, Nicola | |
dc.contributor.author | Kamli-Salino, Sarah | |
dc.contributor.author | Dekeryte, Ruta | |
dc.contributor.author | Hoffmann, Philip | |
dc.contributor.author | Doherty, Mary K | |
dc.contributor.author | Whitfield, Philip D. | |
dc.contributor.author | Delibegović, Mirela | |
dc.contributor.author | Mody, Nimesh | |
dc.date.accessioned | 2024-04-11T23:05:16Z | |
dc.date.available | 2024-04-11T23:05:16Z | |
dc.date.issued | 2023-03-09 | |
dc.identifier | 228985183 | |
dc.identifier | 32204714-127c-4003-b69d-3f7757f09d23 | |
dc.identifier | 36894641 | |
dc.identifier | 85149648102 | |
dc.identifier.citation | Thompson , D , Mahmood , S , Morrice , N , Kamli-Salino , S , Dekeryte , R , Hoffmann , P , Doherty , M K , Whitfield , P D , Delibegović , M & Mody , N 2023 , ' Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice ' , Scientific Reports , vol. 13 , 3937 . https://doi.org/10.1101/2022.07.22.500933 , https://doi.org/10.1038/s41598-023-30759-w | en |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | biorxiv: 197808 | |
dc.identifier.uri | http://aura-test.abdn.ac.uk/handle/2164/20263 | |
dc.description | Acknowledgements This study was supported by funds from the British Heart Foundation (PG16/90/32518) project grant to N. Mody and a PhD studentship to S.M. by the James Mearns Trust and School of Medicine, Medical Sciences and Nutrition, University of Aberdeen (UoA). No potential conflicts of interest relevant to this article are reported. N. Mody and D.T. conceived the study, designed the experiments and wrote the manuscript. D.T., S.M, N. Morrice, R.D., S.K.S, P.H. performed experiments. P.W. and M.D. performed the ceramide analysis, M.D. contributed to the study conception, discussions and reviewed the manuscript. N.Mody is the guarantor of this work and, as such, had full access to all the data in this study and takes responsibility for the integrity and accuracy of the data analysis. The authors thank the UoA animal research facility, qPCR core facility (Institute of Medical Sciences, UoA) and Linda Davidson (NHS Grampian) for their technical contributions regarding animal studies, qPCR and histology respectively and Alison Rutter at UHI for lipidomics support. We thank UoA Masters students Emma Forbes and Nawaf Alsulami for assisting in experiments on ApoE-/- mice. The authors also wish to thank Patrick W F Hadoke (University of Edinburgh) and Heather M Wilson (UoA) for invaluable discussions about mechanisms of atherosclerosis and review of the manuscript, Matteo Zanda, Sergio Dall’Angelo, Chiara Zanato and Ilaria Patruno (all UoA) for medicinal chemistry support. | en |
dc.format.extent | 2325766 | |
dc.language.iso | eng | |
dc.relation.ispartof | Scientific Reports | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject | R Medicine | en |
dc.subject | British Heart Foundation | en |
dc.subject | PG16/90/32518 | en |
dc.subject.lcc | R | en |
dc.title | Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Medical Education | en |
dc.contributor.institution | University of Aberdeen.Medicine, Medical Sciences & Nutrition | en |
dc.contributor.institution | University of Aberdeen.Institute of Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Biological Sciences | en |
dc.contributor.institution | University of Aberdeen.Medical Sciences - Cardiovascular Group | en |
dc.description.status | Peer reviewed | en |
dc.identifier.doi | 10.1101/2022.07.22.500933 | |
dc.identifier.url | https://www.researchsquare.com/article/rs-2183793/v1 | en |
dc.identifier.vol | 13 | en |