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Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

dc.contributor.authorKentistou, Katherine A
dc.contributor.authorLuan, Jian'an
dc.contributor.authorWittemans, Laura B L
dc.contributor.authorHambly, Catherine
dc.contributor.authorKlaric, Lucija
dc.contributor.authorKutalik, Zoltán
dc.contributor.authorSpeakman, John R
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorKendall, Timothy J
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorWilson, James F
dc.contributor.authorJoshi, Peter K
dc.contributor.authorMorton, Nicholas M
dc.date.accessioned2024-02-07T08:18:48Z
dc.date.available2024-02-07T08:18:48Z
dc.date.issued2023-01-19
dc.identifier227044864
dc.identifier7e36eae4-b136-4b88-88f2-9b9a37a566bf
dc.identifier36658113
dc.identifier85146588541
dc.identifier.citationKentistou , K A , Luan , J , Wittemans , L B L , Hambly , C , Klaric , L , Kutalik , Z , Speakman , J R , Wareham , N J , Kendall , T J , Langenberg , C , Wilson , J F , Joshi , P K & Morton , N M 2023 , ' Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene ' , Nature Communications , vol. 14 , 307 . https://doi.org/10.1038/s41467-022-35563-0en
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC9852585
dc.identifier.urihttp://aura-test.abdn.ac.uk/handle/2164/20100
dc.descriptionK.A.K. acknowledges funding from the MRC Doctoral Training Programme in Precision Medicine (MR/N013166/1). L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). Z.K. was supported by the Swiss National Science Foundation (310030-189147). J.F.W. acknowledges funding from the MRC Human Genetics Unit programme grant Quantitative Traits in Health and Disease (U. MC_UU_00007/10). N.M.M. was supported by a Wellcome Trust New Investigator Award (100981/Z/13/Z). We kindly thank Alain Colige and colleagues at the University of Liege for the provision of Adamts14+/– mouse sperm. We would also like to thank the researchers, funders and participants of all the contributing cohorts. Specifically, we thank the UK Biobank Resource, approved under application 19655. ORCADES was supported by the Chief Scientist Office of the Scottish Government (CZB/4/276, CZB/4/710), the Royal Society, the MRC Human Genetics Unit, Arthritis Research UK and the European Union framework program 6 EUROSPAN project (contract no. LSHG-CT-2006-018947). DNA extractions were performed at the Clinical Research Facility in Edinburgh. We would like to acknowledge the invaluable contributions of the research nurses in Orkney, the administrative team in Edinburgh and the people of Orkney. The EPIC-Norfolk study (https://doi.org/10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC-UU_12015/1) and Cancer Research UK (C864/A14136). The genetics work in the EPIC-Norfolk study was funded by the Medical Research Council (MC_PC_13048). We are grateful to all the participants who have been part of the project and to the many members of the study teams at the University of Cambridge who have enabled this research. The Fenland Study (10.22025/2017.10.101.00001) is funded by the Medical Research Council (MC_UU_12015/1). We are grateful to all the volunteers and to the General Practitioners and practice staff for assistance with recruitment. We thank the Fenland Study Investigators, Fenland Study Co-ordination team and the Epidemiology Field, Data and Laboratory teams. We further acknowledge support for genomics from the Medical Research Council (MC_PC_13046).en
dc.format.extent12
dc.format.extent2839294
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectADAMTS Proteins/geneticsen
dc.subjectAdiposity/geneticsen
dc.subjectBody Mass Indexen
dc.subjectGenomeen
dc.subjectObesity/geneticsen
dc.subjectPhenotypeen
dc.subjectWeight Gain/geneticsen
dc.subjectMice, Knockouten
dc.subjectQP Physiologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N013166/1en
dc.subjectMR/R026408/1en
dc.subjectMC_UU_00007/10en
dc.subjectMR/N003284/1en
dc.subjectMC-UU_12015/1en
dc.subjectMC_PC_13048en
dc.subjectMC_PC_13046en
dc.subjectWellcome Trusten
dc.subject100981/Z/13/Zen
dc.subjectCancer Research UKen
dc.subjectC864/A14136en
dc.subject.lccQPen
dc.titleLarge scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity geneen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Energetics Research Groupen
dc.contributor.institutionUniversity of Aberdeen.Environment and Food Securityen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1038/s41467-022-35563-0
dc.identifier.vol14en


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