Cells of the human intestinal tract mapped across space and time
dc.contributor.author | Elmentaite, Rasa | |
dc.contributor.author | Kumasaka, Natsuhiko | |
dc.contributor.author | Roberts, Kenny | |
dc.contributor.author | Fleming, Aaron | |
dc.contributor.author | Dann, Emma | |
dc.contributor.author | King, Hamish W | |
dc.contributor.author | Kleshchevnikov, Vitalii | |
dc.contributor.author | Dabrowska, Monika | |
dc.contributor.author | Pritchard, Sophie | |
dc.contributor.author | Bolt, Liam | |
dc.contributor.author | Vieira, Sara F | |
dc.contributor.author | Mamanova, Lira | |
dc.contributor.author | Huang, Ni | |
dc.contributor.author | Perrone, Francesca | |
dc.contributor.author | Goh Kai'En, Issac | |
dc.contributor.author | Lisgo, Steven N | |
dc.contributor.author | Katan, Matilda | |
dc.contributor.author | Leonard, Steven | |
dc.contributor.author | Oliver, Thomas R W | |
dc.contributor.author | Hook, C Elizabeth | |
dc.contributor.author | Nayak, Komal | |
dc.contributor.author | Campos, Lia S | |
dc.contributor.author | Domínguez Conde, Cecilia | |
dc.contributor.author | Stephenson, Emily | |
dc.contributor.author | Engelbert, Justin | |
dc.contributor.author | Botting, Rachel A | |
dc.contributor.author | Polanski, Krzysztof | |
dc.contributor.author | van Dongen, Stijn | |
dc.contributor.author | Patel, Minal | |
dc.contributor.author | Morgan, Michael D | |
dc.contributor.author | Marioni, John C | |
dc.contributor.author | Bayraktar, Omer Ali | |
dc.contributor.author | Meyer, Kerstin B | |
dc.contributor.author | He, Xiaoling | |
dc.contributor.author | Barker, Roger A | |
dc.contributor.author | Uhlig, Holm H | |
dc.contributor.author | Mahbubani, Krishnaa T | |
dc.contributor.author | Saeb-Parsy, Kourosh | |
dc.contributor.author | Zilbauer, Matthias | |
dc.contributor.author | Clatworthy, Menna R | |
dc.contributor.author | Haniffa, Muzlifah | |
dc.contributor.author | James, Kylie R | |
dc.contributor.author | Teichmann, Sarah A | |
dc.date.accessioned | 2023-12-28T00:19:36Z | |
dc.date.available | 2023-12-28T00:19:36Z | |
dc.date.issued | 2021-09-08 | |
dc.identifier | 221556165 | |
dc.identifier | 4416d7db-1043-4b23-8df0-ae2d16722283 | |
dc.identifier | 34497389 | |
dc.identifier | 85114616944 | |
dc.identifier.citation | Elmentaite , R , Kumasaka , N , Roberts , K , Fleming , A , Dann , E , King , H W , Kleshchevnikov , V , Dabrowska , M , Pritchard , S , Bolt , L , Vieira , S F , Mamanova , L , Huang , N , Perrone , F , Goh Kai'En , I , Lisgo , S N , Katan , M , Leonard , S , Oliver , T R W , Hook , C E , Nayak , K , Campos , L S , Domínguez Conde , C , Stephenson , E , Engelbert , J , Botting , R A , Polanski , K , van Dongen , S , Patel , M , Morgan , M D , Marioni , J C , Bayraktar , O A , Meyer , K B , He , X , Barker , R A , Uhlig , H H , Mahbubani , K T , Saeb-Parsy , K , Zilbauer , M , Clatworthy , M R , Haniffa , M , James , K R & Teichmann , S A 2021 , ' Cells of the human intestinal tract mapped across space and time ' , Nature , vol. 597 , no. 7875 , pp. 250-255 . https://doi.org/10.1038/s41586-021-03852-1 | en |
dc.identifier.issn | 0028-0836 | |
dc.identifier.other | PubMedCentral: PMC8426186 | |
dc.identifier.other | ORCID: /0000-0003-0757-0711/work/128823890 | |
dc.identifier.uri | http://aura-test.abdn.ac.uk/handle/2164/20033 | |
dc.description | Acknowledgements We acknowledge support from the Wellcome Sanger Cytometry Core Facility, Cellular Genetics Informatics team, Cellular Generation and Phenotyping (CGaP) and Core DNA Pipelines. This work was financially supported by the Wellcome Trust (W1T20694, S.A.T.; 203151/Z/16/Z, R. A. Barker.); the European Research Council (646794, ThDefine, S.A.T.); an MRC New Investigator Research Grant (MR/T001917/1, M.Z.); and a project grant from the Great Ormond Street Hospital Children’s Charity, Sparks (V4519, M.Z.). The human embryonic and fetal material was provided by the Joint MRC/Wellcome (MR/R006237/1) Human Developmental Biology Resource (https://www.hdbr.org/). K.R.J. holds a Non-Stipendiary Junior Research Fellowship from Christ’s College, University of Cambridge. M.R.C. is supported by a Medical Research Council Human Cell Atlas Research Grant (MR/S035842/1) and a Wellcome Trust Investigator Award (220268/Z/20/Z). H.W.K. is funded by a Sir Henry Wellcome Fellowship (213555/Z/18/Z). A.F. is funded by a Wellcome PhD Studentship (102163/B/13/Z). K.T.M. is funded by an award from the Chan Zuckerberg Initiative. H.H.U. is supported by the Oxford Biomedical Research Centre (BRC) and the The Leona M. and Harry B. Helmsley Charitable Trust. We thank A. Chakravarti and S. Chatterjee for their contribution to the analysis of the enteric nervous system. We also thank R. Lindeboom and C. Talavera-Lopez for support with epithelium and Visium analysis, respectively; C. Tudor, T. Li and O. Tarkowska for image processing and infrastructure support; A. Wilbrey-Clark and T. Porter for support with Visium library preparation; A. Ross and J. Park for access to and handling of fetal tissue; A. Hunter for assistance in protocol development; D. Fitzpatrick for discussion on developmental intestinal disorders; and J. Eliasova for the graphical images. We thank the tissue donors and their families, and the Cambridge Biorepository for Translational Medicine and Human Developmental Biology Resource, for access to human tissue. This publication is part of the Human Cell Atlas: https://www.humancellatlas.org/publications. | en |
dc.format.extent | 6 | |
dc.format.extent | 21961281 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject | Adult | en |
dc.subject | Aging | en |
dc.subject | Animals | en |
dc.subject | Child | en |
dc.subject | Crohn Disease/pathology | en |
dc.subject | Datasets as Topic | en |
dc.subject | Enteric Nervous System/anatomy & histology | en |
dc.subject | Epithelial Cells/cytology | en |
dc.subject | Female | en |
dc.subject | Fetus/anatomy & histology | en |
dc.subject | Health | en |
dc.subject | Humans | en |
dc.subject | Intestines/cytology | en |
dc.subject | Lymph Nodes/cytology | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Organogenesis | en |
dc.subject | Receptors, IgG/metabolism | en |
dc.subject | Signal Transduction | en |
dc.subject | Spatio-Temporal Analysis | en |
dc.subject | Time Factors | en |
dc.subject | R Medicine | en |
dc.subject | Wellcome Trust | en |
dc.subject | W1T20694 | en |
dc.subject | 203151/Z/16/Z, | en |
dc.subject | 220268/Z/20/Z | en |
dc.subject | 213555/Z/18/Z | en |
dc.subject | 102163/B/13/Z | en |
dc.subject | European Research Council | en |
dc.subject | 646794 | en |
dc.subject | Medical Research Council (MRC) | en |
dc.subject | MR/T001917/1, M.Z | en |
dc.subject | MR/R006237/1 | en |
dc.subject | MR/S035842/1 | en |
dc.subject | Supplementary Data | en |
dc.subject.lcc | R | en |
dc.title | Cells of the human intestinal tract mapped across space and time | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Institute of Medical Sciences | en |
dc.description.status | Peer reviewed | en |
dc.identifier.doi | https://doi.org/10.1038/s41586-021-03852-1 | |
dc.identifier.vol | 597 | en |
dc.identifier.iss | 7875 | en |