dc.contributor.author | Wagner, Stefan | |
dc.contributor.author | Brierley, Daniel I | |
dc.contributor.author | Leeson-Payne, Alasdair | |
dc.contributor.author | Jiang, Wanqing | |
dc.contributor.author | Chianese, Raffaella | |
dc.contributor.author | Lam, Brian Y H | |
dc.contributor.author | Dowsett, Georgina K C | |
dc.contributor.author | Cristiano, Claudia | |
dc.contributor.author | Lyons, David | |
dc.contributor.author | Reimann, Frank | |
dc.contributor.author | Gribble, Fiona M | |
dc.contributor.author | Martinez de Morentin, Pablo B | |
dc.contributor.author | Yeo, Giles S H | |
dc.contributor.author | Trapp, Stefan | |
dc.contributor.author | Heisler, Lora K | |
dc.date.accessioned | 2023-12-06T00:06:18Z | |
dc.date.available | 2023-12-06T00:06:18Z | |
dc.date.issued | 2023-02 | |
dc.identifier | 225811824 | |
dc.identifier | 4aa7cc78-d1e7-4238-8f32-802e40659a00 | |
dc.identifier | 36592795 | |
dc.identifier | 85146136947 | |
dc.identifier.citation | Wagner , S , Brierley , D I , Leeson-Payne , A , Jiang , W , Chianese , R , Lam , B Y H , Dowsett , G K C , Cristiano , C , Lyons , D , Reimann , F , Gribble , F M , Martinez de Morentin , P B , Yeo , G S H , Trapp , S & Heisler , L K 2023 , ' Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression ' , Molecular Metabolism , vol. 68 , 101665 . https://doi.org/10.1016/j.molmet.2022.101665 | en |
dc.identifier.issn | 2212-8778 | |
dc.identifier.other | ORCID: /0000-0002-1823-2913/work/128322172 | |
dc.identifier.other | ORCID: /0000-0002-0684-3215/work/127118034 | |
dc.identifier.uri | http://aura-test.abdn.ac.uk/handle/2164/19993 | |
dc.description | Acknowledgements The authors thank Dr Alasdair S. Garfield, and staff within the University of Aberdeen Medical Research Facility and the Microscopy Facility for their technical assistance. pAAV-mCherry-flex-dtA was a gift from Naoshige Uchida. Work was supported by the Biotechnology and Biological Sciences Research Council (BB/R01857X/1, BB/V016849/1 to LKH and BB/S017593/1 to BYHL), the European Foundation for the Study of Diabetes (Merck Sharpe Dohme grant to ST), the Medical Research Council (MC/PC/15077 to LKH, MR/N02589X/1 to ST and MRC_MC_UU_12012/3 to FR and FMG, and MC_UU_00014/1 to GSHY), the NIH (R01 DK095757 to ST), the Wellcome Trust (WT081713 to LKH, 106262/Z/14/Z, 106263/Z/14/Z to FR and FMG, and 223279/Z/21/Z to DIB) and the Wellcome Trust Institutional Strategic Support Fund to the University of Aberdeen (204815/Z/16/Z to LKH). Next-generation sequencing was performed by IMS Genomics and transcriptomics core facility, which is supported by the MRC (MC_UU_00014/5) and the Wellcome Trust (208363/Z/17/Z), and the Cancer Research UK Cambridge Institute Genomics Core. GKCD is funded by a BBSRC CASE 4-year PhD studentship, co-funded by Novo Nordisk. WJ is supported by a UCL ORS scholarship and a CSC scholarship from the Chinese Government. | en |
dc.format.extent | 11 | |
dc.format.extent | 3486629 | |
dc.language.iso | eng | |
dc.relation.ispartof | Molecular Metabolism | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject | Lorcaserin | en |
dc.subject | Liraglutide | en |
dc.subject | Preproglucagon | en |
dc.subject | Nucleus tractus solitarii | en |
dc.subject | Brainstem | en |
dc.subject | Serotonin 2C receptor | en |
dc.subject | R Medicine | en |
dc.subject | Medical Research Council (MRC) | en |
dc.subject | MR/N02589X/1 | en |
dc.subject | MC/PC/15077 | en |
dc.subject | MRC_MC_UU_12012/3 | en |
dc.subject | Biotechnology and Biological Sciences Research Council (BBSRC) | en |
dc.subject | B/R01857X/1 | en |
dc.subject | BB/V016849/1 | en |
dc.subject | BB/S017593/1 | en |
dc.subject | Wellcome Trust | en |
dc.subject | WT081713 | en |
dc.subject | 106262/Z/14/Z | en |
dc.subject | 106263/Z/14/Z | en |
dc.subject | 223279/Z/21/Z | en |
dc.subject | 208363/Z/17/Z | en |
dc.subject.lcc | R | en |
dc.title | Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Rowett Institute | en |
dc.contributor.institution | University of Aberdeen.Aberdeen Cardiovascular and Diabetes Centre | en |
dc.description.status | Peer reviewed | en |
dc.identifier.doi | https://doi.org/10.1016/j.molmet.2022.101665 | |
dc.identifier.vol | 68 | en |