dc.contributor.author | Gibson, Patrick H. | |
dc.contributor.author | Croal, Bernard L. | |
dc.contributor.author | Small, Gary R. | |
dc.contributor.author | Ifezulike, Ada I. | |
dc.contributor.author | Gibson, George | |
dc.contributor.author | Jeffrey, Robert R. | |
dc.contributor.author | Buchan, Keith G. | |
dc.contributor.author | El-Shafei, Hussein | |
dc.contributor.author | Hillis, Graham S. | |
dc.contributor.author | Cuthbertson, Brian | en |
dc.date.accessioned | 2008-04-10T15:18:29Z | |
dc.date.available | 2008-04-10T15:18:29Z | |
dc.date.issued | 2007-11 | |
dc.identifier.citation | Gibson, P.H, Croal, B.L., Cuthbertson, B.H, Small, G.R., Ifezulike, A.I., Gibson, G., Buchan, K.G., El-Shafei, H., and Hillis, G.S. (2007). Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. American Heart Journal [Online], 154(5), pp.995-1002. Available from: http://www.sciencedirect.com/science/journal/00028703 [Accessed 10 April 2008] | en |
dc.identifier.issn | 1097-6744 | |
dc.identifier.other | PURE: 196848 | |
dc.identifier.uri | http://hdl.handle.net/2164/198 | |
dc.description.abstract | Background: An elevated preoperative white blood cell count has been associated with a worse outcome after coronary artery bypass grafting (CABG). Leukocyte subtypes, and particularly the neutrophil-lymphocyte (N/L) ratio, may however, convey superior prognostic information. We hypothesized that the N/L ratio would predict the outcome of patients undergoing surgical revascularization. Methods: Baseline clinical details were obtained prospectively in 1938 patients undergoing CABG. The differential leukocyte was measured before surgery, and patients were followed-up 3.6 years later. The primary end point was all-cause mortality. Results: The preoperative N/L ratio was a powerful univariable predictor of mortality (hazard ratio [HR] 1.13 per unit, P < .001). In a backward conditional model, including all study variables, it remained a strong predictor (HR 1.09 per unit, P = .004). In a further model, including the European system for cardiac operative risk evaluation, the N/L ratio remained an independent predictor (HR 1.08 per unit, P = .008). Likewise, it was an independent predictor of cardiovascular mortality and predicted death in the subgroup of patients with a normal white blood cell count. This excess hazard was concentrated in patients with an N/L ratio in the upper quartile (>3.36). Conclusion: An elevated N/L ratio is associated with a poorer survival after CABG. This prognostic utility is independent of other recognized risk factors. | en |
dc.format.extent | 318789 bytes | |
dc.format.extent | 7 p. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Coronary Artery Bypass | en |
dc.subject | Lymphocytes | en |
dc.subject | Myocardial Ischemia | en |
dc.subject | Neutrophils | en |
dc.subject.lcc | RD Surgery | en |
dc.title | Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting | en |
dc.type | Journal Article | en |
dc.type | Text | en |
dc.contributor.institution | University of Aberdeen, School of Medicine & Dentistry, Division of Applied Medicine | en |
dc.contributor.institution | University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciences | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Author version | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.ahj.2007.06.043 | |