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Experiences of running a stratified medicine adaptive platform trial : Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer

dc.contributor.authorFOCUS4 Trial Investigators
dc.date.accessioned2023-08-24T23:06:35Z
dc.date.available2023-08-24T23:06:35Z
dc.date.issued2022-04-01
dc.identifier212441247
dc.identifierdc9eaf2a-bbcc-4fb8-baeb-cad53369e816
dc.identifier000751933300001
dc.identifier85124365121
dc.identifier.citationFOCUS4 Trial Investigators 2022 , ' Experiences of running a stratified medicine adaptive platform trial : Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer ' , Clinical Trials , vol. 19 , no. 2 , pp. 146-157 . https://doi.org/10.1177/17407745211069879en
dc.identifier.issn1740-7745
dc.identifier.otherRIS: urn:C98A67A9776A8D9632D418E08FCEDB42
dc.identifier.otherORCID: /0000-0002-8402-8670/work/107489650
dc.identifier.urihttp://aura-test.abdn.ac.uk/handle/2164/19747
dc.descriptionFunding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: FOCUS4 was co-funded by the Medical Research Council (MRC)/National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme and Cancer Research UK (CRUK) in April 2013. A subsequent AstraZeneca educational grant in 2017 funded the translational aspects of FOCUS4-C. Supply and distribution of AZD8931 for FOCUS-D and AZD1775 for FOCUS4-C were provided by AstraZeneca Ltd. Supply and distribution of aspirin and placebo for FOCUS4-B were provided by Bayer. The MRC Clinical Trials Unit at UCL receives core funding from the MRC within UK Research and Innovation (UKRI) (Budget: MC_UU_12023/20).en
dc.format.extent12
dc.format.extent1080596
dc.language.isoeng
dc.relation.ispartofClinical Trialsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectMetastaticen
dc.subjectcolorectal canceren
dc.subjectbiomarkeren
dc.subjectstratifieden
dc.subjectclinical trialen
dc.subjectmulti-arm multi-stageen
dc.subjectadaptiveen
dc.subjectcomplex innovative designen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UU_12023/20en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectCancer Research UKen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleExperiences of running a stratified medicine adaptive platform trial : Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal canceren
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Health Services Research Uniten
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1177/17407745211069879
dc.identifier.vol19en
dc.identifier.iss2en


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