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The association between mitochondrial DNA abundance and stroke : A combination of multivariable-adjusted survival and Mendelian randomization analyses

dc.contributor.authorMartens, Leon G
dc.contributor.authorLuo, Jiao
dc.contributor.authorWermer, Marieke J H
dc.contributor.authorWillems van Dijk, Ko
dc.contributor.authorHägg, Sara
dc.contributor.authorGrassmann, Felix
dc.contributor.authorNoordam, Raymond
dc.contributor.authorvan Heemst, Diana
dc.date.accessioned2023-04-24T23:05:12Z
dc.date.available2023-04-24T23:05:12Z
dc.date.issued2022-08-01
dc.identifier218833567
dc.identifier1c1736c3-f9d5-49be-9f10-8cbbd4949e76
dc.identifier35793595
dc.identifier85133224453
dc.identifier.citationMartens , L G , Luo , J , Wermer , M J H , Willems van Dijk , K , Hägg , S , Grassmann , F , Noordam , R & van Heemst , D 2022 , ' The association between mitochondrial DNA abundance and stroke : A combination of multivariable-adjusted survival and Mendelian randomization analyses ' , Atherosclerosis , vol. 354 , pp. 1-7 . https://doi.org/10.1016/j.atherosclerosis.2022.06.1012en
dc.identifier.issn0021-9150
dc.identifier.otherORCID: /0000-0003-1390-7528/work/122953433
dc.identifier.urihttp://aura-test.abdn.ac.uk/handle/2164/19533
dc.descriptionAcknowledgements The authors are grateful to the UK Biobank for allowing us the use of their data. The analyses done in UK Biobank were done under project number 56340. Furthermore, the authors acknowledge the participants and investigators of the MEGASTROKE consortium and the FinnGen Biobank who contributed to the summary statistics data which are made available for further studies. Financial support This work was supported by the VELUX Stiftung [grant number 1156] to DvH and RN, and JL was supported by the China Scholarship Counsel [No.201808500155]. RN was supported by an innovation grant from the Dutch Heart Foundation [grant number 2019T103 to R.N.]. Parts of this work were funded by the Åke Wibergs Foundation (grant number M19-0294 to F.G).en
dc.format.extent7
dc.format.extent1451582
dc.language.isoeng
dc.relation.ispartofAtherosclerosisen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectCardiovascular diseasesen
dc.subjectHemorrhagic strokeen
dc.subjectIschemic strokeen
dc.subjectMendelian randomizationen
dc.subjectMitochondrial DNA copy numbersen
dc.subjectMitochondrial functionen
dc.subjectReactive oxygen speciesen
dc.subjectR Medicine (General)en
dc.subjectCardiology and Cardiovascular Medicineen
dc.subject.lccR1en
dc.titleThe association between mitochondrial DNA abundance and stroke : A combination of multivariable-adjusted survival and Mendelian randomization analysesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1016/j.atherosclerosis.2022.06.1012
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85133224453&partnerID=8YFLogxKen
dc.identifier.vol354en


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