dc.contributor.author | Maina, Mahmoud B. | |
dc.contributor.author | Al-Hilaly, Youssra K. | |
dc.contributor.author | Oakley, Sebastian | |
dc.contributor.author | Burra, Gunasekhar | |
dc.contributor.author | Khanom, Tahmida | |
dc.contributor.author | Biasetti, Luca | |
dc.contributor.author | Mengham, Kurtis | |
dc.contributor.author | Marshall, Karen | |
dc.contributor.author | Harrington, Charles R. | |
dc.contributor.author | Wischik, Claude M. | |
dc.contributor.author | Serpell, Louise C. | |
dc.date.accessioned | 2023-04-17T23:09:39Z | |
dc.date.available | 2023-04-17T23:09:39Z | |
dc.date.issued | 2022-10-15 | |
dc.identifier | 220543950 | |
dc.identifier | 56855ef0-6574-4ab4-8bac-8e00351c1aec | |
dc.identifier | 85136298107 | |
dc.identifier | 35961386 | |
dc.identifier | 35961386 | |
dc.identifier | 35961386 | |
dc.identifier.citation | Maina , M B , Al-Hilaly , Y K , Oakley , S , Burra , G , Khanom , T , Biasetti , L , Mengham , K , Marshall , K , Harrington , C R , Wischik , C M & Serpell , L C 2022 , ' Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro ' , Journal of Molecular Biology , vol. 434 , no. 19 , 167785 . https://doi.org/10.1016/j.jmb.2022.167785 | en |
dc.identifier.issn | 0022-2836 | |
dc.identifier.uri | http://aura-test.abdn.ac.uk/handle/2164/19515 | |
dc.description | Acknowledgements The authors are grateful to M Goedert (MRC Laboratory of Molecular Biology, Cambridge, UK) for ex-vivo paired helical filaments which were kindly contributed by Bernandino Ghetti (Indiana University, USA). The authors are very grateful to Urmi Sengupta, Nemil Bhatt and Rakez Kayed (University of Texas, USA) for providing ex-vivo tau oligomers. TEM work was performed at the University of Sussex’s Electron microscopy imaging centre (EMC), funded by the School of Life Sciences, the Wellcome Trust (095605/Z/11/A, 208348/Z/17/Z) and the RM Phillips Trust. The authors thank Dr Pascale Schellenberger for valuable support. Funding This work was supported by funding from Alzheimer’s Society [AS-PG-16b-010] awarded to LCS and funding MBM. MBM is funded by the Alzheimer’s Association. YA is supported by WisTa Laboratories Ltd (PAR1596). The work was supported by ARUK South Coast Network. GB was supported by European Molecular Biology Organisation (EMBO) Short-Term Fellowship award (EMBO-STF 7674). LCS is supported by BBSRC [BB/S003657/1]. Urmi Sengupta, Nemil Bhatt, Rakez Kayed acknowledge the funding that supports their contribution (NIH grants to R.K: R01 AG054025 and U24AG072458). | en |
dc.format.extent | 14 | |
dc.format.extent | 2977775 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Molecular Biology | en |
dc.subject | Alzheimer's disease | en |
dc.subject | dityrosine | en |
dc.subject | oxidative stress | en |
dc.subject | paired helical filaments | en |
dc.subject | tau | en |
dc.subject | QH301 Biology | en |
dc.subject | Biophysics | en |
dc.subject | Structural Biology | en |
dc.subject | Molecular Biology | en |
dc.subject.lcc | QH301 | en |
dc.title | Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Neuroscience | en |
dc.contributor.institution | University of Aberdeen.Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Institute of Medical Sciences | en |
dc.contributor.institution | University of Aberdeen.Applied Medicine | en |
dc.description.status | Peer reviewed | en |
dc.identifier.doi | https://doi.org/10.1016/j.jmb.2022.167785 | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85136298107&partnerID=8YFLogxK | en |
dc.identifier.vol | 434 | en |
dc.identifier.iss | 19 | en |