| dc.contributor.author | Higham, Jonathan | |
| dc.contributor.author | Kerr, Lyndsay | |
| dc.contributor.author | Zhang, Qian | |
| dc.contributor.author | Walker, Rosie M | |
| dc.contributor.author | Harris, Sarah E | |
| dc.contributor.author | Howard, David M | |
| dc.contributor.author | Hawkins, Emma L | |
| dc.contributor.author | Sandu, Anca-Larisa | |
| dc.contributor.author | Steele, J Douglas | |
| dc.contributor.author | Waiter, Gordon D | |
| dc.contributor.author | Murray, Alison D | |
| dc.contributor.author | Evans, Kathryn L | |
| dc.contributor.author | McIntosh, Andrew M | |
| dc.contributor.author | Visscher, Peter M | |
| dc.contributor.author | Deary, Ian J | |
| dc.contributor.author | Cox, Simon R | |
| dc.contributor.author | Sproul, Duncan | |
| dc.date.accessioned | 2023-01-24T00:05:43Z | |
| dc.date.available | 2023-01-24T00:05:43Z | |
| dc.date.issued | 2022-10-17 | |
| dc.identifier | 220071852 | |
| dc.identifier | 06140561-ec17-44a1-8fdc-1a698def2ff8 | |
| dc.identifier | 36253871 | |
| dc.identifier | 85139819868 | |
| dc.identifier.citation | Higham , J , Kerr , L , Zhang , Q , Walker , R M , Harris , S E , Howard , D M , Hawkins , E L , Sandu , A-L , Steele , J D , Waiter , G D , Murray , A D , Evans , K L , McIntosh , A M , Visscher , P M , Deary , I J , Cox , S R & Sproul , D 2022 , ' Local CpG density affects the trajectory and variance of age-associated DNA methylation changes ' , Genome Biology , vol. 23 , no. 1 , 216 . https://doi.org/10.1186/s13059-022-02787-8 | en |
| dc.identifier.issn | 1474-760X | |
| dc.identifier.other | ORCID: /0000-0002-5555-4129/work/121536111 | |
| dc.identifier.other | ORCID: /0000-0002-5313-9845/work/121540264 | |
| dc.identifier.uri | http://aura-test.abdn.ac.uk/handle/2164/19407 | |
| dc.description | Acknowledgements We thank Riccardo Marioni, Chris Haley, Ailith Ewing, David Porteous, Chris Ponting, Rob Illingworth, Tamir Chandra, Sara Hagg, Yunzhang Wang, Chantriolnt-Andreas Kapourani, Nick Gilbert, Hannes Becher and members of the Sproul lab for helpful discussions about the study and the manuscript. This work has made use of the resources provided by the University of Edinburgh digital research services and the MRC IGC compute cluster. We are grateful to all the families who took part in the Generation Scotland study along with the general practitioners and the Scottish School of Primary Care for their help in recruiting them, and the entire Generation Scotland team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, healthcare assistants, and nurses. Peer review information Anahita Bishop and Kevin Pang were the primary editors of this article and managed its editorial process and peer review in collaboration with the rest of the editorial team. Review history The review history is available as Additional file 3. Funding DS is a Cancer Research UK Career Development fellow (reference C47648/A20837), and work in his laboratory is also supported by an MRC university grant to the MRC Human Genetics Unit. LK is a cross-disciplinary postdoctoral fellow supported by funding from the University of Edinburgh and Medical Research Council (MC_UU_00009/2). S.R.C. and I.J.D. were supported by a National Institutes of Health (NIH) research grant R01AG054628, and S.R.C is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (221890/Z/20/Z). AMM is supported by the Wellcome Trust (104036/Z/14/Z, 216767/Z/19/Z, 220857/Z/20/Z) and UKRI MRC (MC_PC_17209, MR/S035818/1). PMV acknowledges support from the Australian National Health and Medical Research Council (1113400) and the Australian Research Council (FL180100072). DMH is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Reference 213674/Z/18/Z). We thank the LBC1936 participants and team members who contributed to the study. Further study information can be found at https://www.ed.ac.uk/lothian-birth-cohorts. The LBC1936 is supported by a jointly funded grant from the BBSRC and ESRC (BB/W008793/1), and also by Age UK (Disconnected Mind project), the Medical Research Council (G0701120, G1001245, MR/M013111/1, MR/R024065/1), and the University of Edinburgh. Genotyping of LBC1936 was funded by the BBSRC (BB/F019394/1), and methylation typing of LBC1936 was supported by Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. Work on Generation Scotland was supported by a Wellcome Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL; 104036/Z/14/Z) to AMM, KLE, and others, and an MRC Mental Health Data Pathfinder Grant (MC_PC_17209) to AMM. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). DNA methylation profiling and analysis of the GS:SFHS samples was supported by Wellcome Investigator Award 220857/Z/20/Z and Grant 104036/Z/14/Z (PI: AM McIntosh) and through funding from NARSAD (Ref: 27404; awardee: Dr DM Howard) and the Royal College of Physicians of Edinburgh (Sim Fellowship; Awardee: Dr HC Whalley). | en |
| dc.format.extent | 28 | |
| dc.format.extent | 36273775 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Genome Biology | en |
| dc.subject | SDG 3 - Good Health and Well-being | en |
| dc.subject | R Medicine | en |
| dc.subject | Cancer Research UK | en |
| dc.subject | C47648/A20837 | en |
| dc.subject | Medical Research Council (MRC) | en |
| dc.subject | MC_UU_00009/2 | en |
| dc.subject | MC_PC_17209 | en |
| dc.subject | MR/S035818/1 | en |
| dc.subject | G0701120 | en |
| dc.subject | G1001245 | en |
| dc.subject | MR/M013111/1 | en |
| dc.subject | Wellcome Trust | en |
| dc.subject | 221890/Z/20/Z | en |
| dc.subject | 104036/Z/14/Z | en |
| dc.subject | 216767/Z/19/Z | en |
| dc.subject | 220857/Z/20/Z | en |
| dc.subject | MR/R024065/1 | en |
| dc.subject | Economic and Social Research Council (ESRC) | en |
| dc.subject | BB/W008793/1 | en |
| dc.subject | Biotechnology and Biological Sciences Research Council (BBSRC) | en |
| dc.subject | BB/W008793/1 | en |
| dc.subject | BB/F019394/1) | en |
| dc.subject | Chief Scientist Office (CSO) | en |
| dc.subject | CZD/16/6 | en |
| dc.subject | Other | en |
| dc.subject | HR03006 | en |
| dc.subject | Supplementary Information | en |
| dc.subject.lcc | R | en |
| dc.title | Local CpG density affects the trajectory and variance of age-associated DNA methylation changes | en |
| dc.type | Journal article | en |
| dc.contributor.institution | University of Aberdeen.Medical Sciences | en |
| dc.contributor.institution | University of Aberdeen.Institute of Medical Sciences | en |
| dc.contributor.institution | University of Aberdeen.Aberdeen Biomedical Imaging Centre | en |
| dc.contributor.institution | University of Aberdeen.Applied Medicine | en |
| dc.description.status | Peer reviewed | en |
| dc.identifier.doi | 10.1186/s13059-022-02787-8 | |
| dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85139819868&partnerID=8YFLogxK | en |
