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Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART) : a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

dc.contributor.authorWong, Charis
dc.contributor.authorDakin, Rachel S
dc.contributor.authorWilliamson, Jill
dc.contributor.authorNewton, Judith
dc.contributor.authorSteven, Michelle
dc.contributor.authorColville, Shuna
dc.contributor.authorStavrou, Maria
dc.contributor.authorGregory, Jenna M
dc.contributor.authorElliott, Elizabeth
dc.contributor.authorMehta, Arpan R
dc.contributor.authorChataway, Jeremy
dc.contributor.authorSwingler, Robert J
dc.contributor.authorParker, Richard Anthony
dc.contributor.authorWeir, Christopher J
dc.contributor.authorStallard, Nigel
dc.contributor.authorParmar, Mahesh K B
dc.contributor.authorMacleod, Malcolm R
dc.contributor.authorPal, Suvankar
dc.contributor.authorChandran, Siddharthan
dc.date.accessioned2022-11-02T00:10:22Z
dc.date.available2022-11-02T00:10:22Z
dc.date.issued2022-07-07
dc.identifier218218697
dc.identifier60f2c972-d966-48b8-be89-0e401f06a579
dc.identifier85133648276
dc.identifier.citationWong , C , Dakin , R S , Williamson , J , Newton , J , Steven , M , Colville , S , Stavrou , M , Gregory , J M , Elliott , E , Mehta , A R , Chataway , J , Swingler , R J , Parker , R A , Weir , C J , Stallard , N , Parmar , M K B , Macleod , M R , Pal , S & Chandran , S 2022 , ' Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART) : a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease ' , BMJ Open , vol. 12 , no. 7 , e064173 . https://doi.org/10.1136/bmjopen-2022-064173en
dc.identifier.issn2044-6055
dc.identifier.otherBibtex: Wonge064173
dc.identifier.otherBibtex: Wonge064173
dc.identifier.otherORCID: /0000-0003-3337-4079/work/119826028
dc.identifier.urihttp://aura-test.abdn.ac.uk/handle/2164/19246
dc.descriptionAcknowledgements The authors would like to thank all the MND-SMART participants and collaborators involved in the trial. Particular thanks to the trial public patient involvement group who informed trial design and patient facing documents. The authors would like to thank the members of the Independent Data Monitoring Committee: Stephen Wroe (Chair), Camille Caroll, Sue Todd; and the members of the Trial Steering Committee: Helen Ford (Chair), Hadi Manji, James Carpenter, Beverley Gray and former member Alan Gray. Additional thanks to Ronnie Harkess for designing the trial database and Catriona Keerie for statistical analysis. Particularly thanks also to all research nurses and practitioners involved in the trial. MND-SMART is cosponsored by University of Edinburgh and NHS Lothian Academic and Clinical Central Office for Research and Development (ACCORD). The current MND-SMART sites and investigators are; Aberdeen Royal Cornhill Hospital, NHS Grampian, Dr Callum Duncan; Barts Health NHS Trust, Royal London Hospital, Dr Aleksandar Radunovic; Birmingham Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Dr Venkataramanan Srinivasan; Cambridge University Hospitals NHS Foundation Trust, Dr Rhys Roberts; Cardiff and Value University Health Board, University Hospital Wales, Dr Ken Dawson; Dundee Ninewells Hospital, NHS Tayside, Dr Ian Morrison, Edinburgh Anne Rowling Regenerative Neurology Clinic, NHS Lothian, Dr Suvankar Pal, Royal Devon and Exeter NHS Foundation Trust, Dr Timothy Harrower, Glasgow Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Dr George Gorrie, Inverness Raigmore Hospital, NHS Highland, Dr Javier Carod-Artal, Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust, Dr Clare Galton, Newcastle MND Care and Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Dr Timothy Williams; Norfolk and Norwich University Hospitals NHS Foundation Trust, Dr Godwin Mamutse; Salford Royal NHS Foundation Trust, Dr Hisham Hamdalla, University Hospital Southampton NHS Foundation Trust, Dr Ashwin Pinto, St George’s University Hospital NHS Foundation Trust, Dr Pablo Garcia Reitboeck; West Suffolk NHS Foundation Trust, Dr Francesca Crawley Funding MND-SMART is funded by grants from MND Scotland, My Name’5 Doddie Foundation (DOD/14/15) and specific donations to the Euan MacDonald Centre. CW, RAP and MiS were supported in this work by NHS Lothian via Edinburgh Clinical Trials Unit. SCh receives funding from UK Research and Innovation (Medical Research Council) (DRI-CORE-2017-EDI). The study funders have no role in study design, data collection, data analysis, data interpretation or writing of publications. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. EE is a clinical academic fellow jointly funded by MND Scotland (MNDS) and the Chief Scientist Office (CSO) (217ARF R45951). ARM is a Lady Edith Wolfson Clinical Fellow and is jointly funded by the Medical Research Council (MRC) and the Motor Neurone Disease Association (MR/ R001162/1).en
dc.format.extent11
dc.format.extent1423729
dc.language.isoeng
dc.relation.ispartofBMJ Openen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectDRI-CORE-2017-EDIen
dc.subjectMR/ R001162/1en
dc.subjectOtheren
dc.subjectDOD/14/15en
dc.subject217ARF R45951en
dc.subjectChief Scientist Office (CSO)en
dc.subject217ARF R45951en
dc.subject.lccRen
dc.titleMotor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART) : a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron diseaseen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2022-064173
dc.identifier.urlhttps://bmjopen.bmj.com/content/12/7/e064173en
dc.identifier.vol12en
dc.identifier.iss7en


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