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IL-13 is a driver of COVID-19 severity

dc.contributor.authorDonlan, Alexandra N.
dc.contributor.authorSutherland, Tara E.
dc.contributor.authorMarie, Chelsea
dc.contributor.authorPreissner, Saskia
dc.contributor.authorBradley, Benjamin T.
dc.contributor.authorCarpenter, Rebecca M.
dc.contributor.authorSturek, Jeffrey M.
dc.contributor.authorMa, Jennie Z.
dc.contributor.authorMoreau, G. Brett
dc.contributor.authorDonowitz, Jeffrey R.
dc.contributor.authorBuck, Gregory A.
dc.contributor.authorSerrano, Myrna G.
dc.contributor.authorBurgess, Stacey L.
dc.contributor.authorAbhyankar, Mayuresh M.
dc.contributor.authorMura, Cameron
dc.contributor.authorBourne, Philip E.
dc.contributor.authorPreissner, Robert
dc.contributor.authorYoung, Mary K.
dc.contributor.authorLyons, Genevieve R.
dc.contributor.authorLoomba, Johanna J.
dc.contributor.authorRatcliffe, Sarah J.
dc.contributor.authorPoulter, Melinda D.
dc.contributor.authorMathers, Amy J.
dc.contributor.authorDay, Anthony J.
dc.contributor.authorMann, Barbara J
dc.contributor.authorAllen, Judith E.
dc.contributor.authorJr, William A. Petri
dc.date.accessioned2022-10-29T23:09:58Z
dc.date.available2022-10-29T23:09:58Z
dc.date.issued2021-08-09
dc.identifier219634894
dc.identifierc2d4cfd5-86ef-4473-9f71-cb0e1c7e77da
dc.identifier85112298391
dc.identifier.citationDonlan , A N , Sutherland , T E , Marie , C , Preissner , S , Bradley , B T , Carpenter , R M , Sturek , J M , Ma , J Z , Moreau , G B , Donowitz , J R , Buck , G A , Serrano , M G , Burgess , S L , Abhyankar , M M , Mura , C , Bourne , P E , Preissner , R , Young , M K , Lyons , G R , Loomba , J J , Ratcliffe , S J , Poulter , M D , Mathers , A J , Day , A J , Mann , B J , Allen , J E & Jr , W A P 2021 , ' IL-13 is a driver of COVID-19 severity ' , JCI Insight , vol. 6 , no. 15 , 150107 . https://doi.org/10.1172/jci.insight.150107en
dc.identifier.issn2379-3708
dc.identifier.otherORCID: /0000-0001-9334-8206/work/96260899
dc.identifier.urihttp://aura-test.abdn.ac.uk/handle/2164/19241
dc.descriptionFunding Information: We wish to thank the families who provided consent for autopsy and the patients with COVID-19 who provided plasma samples. We thank Mike Solga, University of Virginia Flow Cytometry Core, for cytokine measurements, Ron Grider for electronic medical record data extraction, Panwichit Tongvichit for plasma sample collection, Patcharin Pramoonjago for Biomedical Tissue Repository support, Jennifer White for IRB protocol preparation, Sanford Feldman for comparative medicine support, Desiree Marshall and Stella Pearson for the support of the pathology specimens, Indika Mallawaarachchi and Arti Patel for N3C analyses, and Nicholas R. Natale and William A. Petri for technical support. SARS-CoV-2 Hong Kong/ VM20001061/2020 was obtained from BEI Resources. Funding: This work was supported by grants from the Manning Family Foundation, Ivy Foundation, Henske Family, and NIH R01 AI124214 (to WAP); by R01 AI148518 (to CM); by NIH R01 AI146257 (to SB); by NIH UL1TR003015/KL2TR003016 (to JMS); by the Department of Laboratory Medicine and Pathology, University of Washington (to BTB); by the Wellcome Trust 106898/A/15/Z, Wellcome Trust 203128/Z/16/Z and MRC-UK MR/K01207X/2 (to JEA); by the Asthma UK & Medical Research Foundation MRFAUK-2015-302, SP (to TES); by the German Research Foundation (DFG): PR1562/1-1, TRR295, and KFO339 (to SP and RP); and by NCATS U24 TR002306 and UVA UL1 TR003015 (to JJL and SJR). Portions of this work were also supported by the UVA School of Data Science and by NSF Career award MCB-1350957 (to CM).en
dc.format.extent17
dc.format.extent6920969
dc.language.isoeng
dc.relation.ispartofJCI Insighten
dc.subjectAnimalsen
dc.subjectCOVID-19/blooden
dc.subjectDisease Modelsen
dc.subjectAnimalen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInterleukin-13/blooden
dc.subjectLung/immunologyen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectInbred C57BLen
dc.subjectSARS-CoV-2/immunologyen
dc.subjectSeverity of Illness Indexen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titleIL-13 is a driver of COVID-19 severityen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1172/jci.insight.150107
dc.identifier.vol6en
dc.identifier.iss15en


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