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Population genetics and microevolution of clinical Candida glabrata reveals recombinant sequence types and hyper-variation within mitochondrial genomes, virulence genes and drug-targets

dc.contributor.authorHelmstetter, Nicolas
dc.contributor.authorChybowska, Aleksandra D
dc.contributor.authorDelaney, Christopher
dc.contributor.authorda Silva Dantas, Alessandra
dc.contributor.authorGifford, Hugh
dc.contributor.authorWacker, Theresa
dc.contributor.authorMunro, Carol
dc.contributor.authorWarris, Adilia
dc.contributor.authorJones, Brian L.
dc.contributor.authorCuomo, Christina A
dc.contributor.authorWilson, Duncan
dc.contributor.authorRamage, Gordon
dc.contributor.authorFarrer, Rhys A
dc.date.accessioned2022-08-24T09:44:01Z
dc.date.available2022-08-24T09:44:01Z
dc.date.issued2022-05
dc.identifier212990677
dc.identifierb94784b3-b26a-4447-9f24-4065a0fe4feb
dc.identifier85129998170
dc.identifier.citationHelmstetter , N , Chybowska , A D , Delaney , C , da Silva Dantas , A , Gifford , H , Wacker , T , Munro , C , Warris , A , Jones , B L , Cuomo , C A , Wilson , D , Ramage , G & Farrer , R A 2022 , ' Population genetics and microevolution of clinical Candida glabrata reveals recombinant sequence types and hyper-variation within mitochondrial genomes, virulence genes and drug-targets ' , Genetics , vol. 221 , no. 1 , iyac031 . https://doi.org/10.1093/genetics/iyac031en
dc.identifier.issn0016-6731
dc.identifier.urihttps://hdl.handle.net/2164/19099
dc.descriptionAcknowledgments R.A.F, D.W., T.W., and A.W. are supported by the Medical Research Council Centre for Medical Mycology MR/N006364/2. R.A.F. is supported by a Wellcome Trust Seed Award (215239/Z/19/Z). D.W. is supported by a Wellcome Trust Senior Research Fellowship (214317/Z/18/Z). C.A.M is funded by the European Union's Horizon 2020, Innovative Training Network: FunHoMic (grant N° 812969) and consortium ‘Host-Directed Medicine in invasive FUNgal infections’—HDM-FUN (Grant Agreement 847507). The authors thank Zeynab Heidari and Elaina Collie725 Duguid of the Centre for Genome-Enabled Biology and Medicine , University of Aberdeen for their support and assistance in this work. We would also like to thank Dr. Lucy van Dorp for valuable suggestions for running ADMIXTURE, and Prof. Ian Stansfield for useful discussions.en
dc.format.extent1765705
dc.language.isoeng
dc.relation.ispartofGeneticsen
dc.subjectCandida glabrataen
dc.subjectgenome sequencingen
dc.subjectepidemiologyen
dc.subjectcandidiasisen
dc.subjectmicroevolutionen
dc.subjectmitochondriaen
dc.subjectdrug-resistanceen
dc.subjectevolutionen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/2en
dc.subjectWellcome Trusten
dc.subject215239/Z/19/Zen
dc.subject214317/Z/18/Zen
dc.subjectOtheren
dc.subject847507en
dc.subject.lccRen
dc.titlePopulation genetics and microevolution of clinical Candida glabrata reveals recombinant sequence types and hyper-variation within mitochondrial genomes, virulence genes and drug-targetsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1093/genetics/iyac031


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