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Positive feedback regulation of fzd7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

dc.contributor.authorYamamoto, Takayoshi
dc.contributor.authorKambayashi, Yuta
dc.contributor.authorOtsuka, Yuta
dc.contributor.authorAfouda, Boni
dc.contributor.authorGiuraniuc, Vasile
dc.contributor.authorMichiue, Tatsuo
dc.contributor.authorHoppler, Stefan
dc.date.accessioned2022-08-15T12:48:01Z
dc.date.available2022-08-15T12:48:01Z
dc.date.issued2022-08-09
dc.identifier217813635
dc.identifierf7913e66-18e1-4bb4-9581-eca7decdcb61
dc.identifier85135548598
dc.identifier35942683
dc.identifier.citationYamamoto , T , Kambayashi , Y , Otsuka , Y , Afouda , B , Giuraniuc , V , Michiue , T & Hoppler , S 2022 , ' Positive feedback regulation of fzd7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate ' , eLife , vol. 11 , 73818 . https://doi.org/10.7554/eLife.73818en
dc.identifier.urihttps://hdl.handle.net/2164/19064
dc.descriptionAcknowledgements We thank Dr. Yukio Nakamura (Aberdeen University, UK; Present address: Repertoire Genesis Inc., Japan.) and Dr. Masanori Taira (Chuo University, Japan) for their help in initiating this project; Dr. Takehiko Nakamura (Seikagaku Corporation, Japan) for NAH46 antibody and hybridoma; Dr. Osamu Yoshie (Kindai University, Japan) for HepSS-1 hybridoma; Dr. Makoto Matsuyama (Shigei Medical Research Institute, Japan) for the contribution to the generation of NAH46 and HepSS-1 antibody from the hybridomas; Dr. Steven D. Aird for technical editing of the manuscript. This international collaboration was supported in part by Daiwa Anglo-Japanese Foundation (12969/13787 to T.Y., B.A., T.M., and S.H.); with additional research support in Japan from MEXT/JSPS KAKENHI (19K16138 to T.Y., 18K06244/21K06183 to T.Y. and T.M.); and in the United Kingdom from BHF (RG/18/8/33673 to S.H.) and BBSRC (BB/N021924/1; BB/M001695/1 to S.H.). S.H. was a Royal Society/Leverhulme Trust Senior Research Fellow (SRF\R1\191017).en
dc.format.extent21
dc.format.extent6313811
dc.language.isoeng
dc.relation.ispartofeLifeen
dc.subjectWnt signalen
dc.subjectFrizzleden
dc.subjectHearten
dc.subjectGene Regulatory Circuiten
dc.subjectMorphogenen
dc.subjectxenopusen
dc.subjectR Medicineen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/N021924/1en
dc.subjectBB/M001695/1en
dc.subjectOtheren
dc.subjectSRF\R1\191017en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titlePositive feedback regulation of fzd7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfateen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.7554/eLife.73818
dc.identifier.vol11en


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