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Improved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction

dc.contributor.authorMehta, Arpan R.
dc.contributor.authorBarton, Samantha K.
dc.contributor.authorMcDade, Karina
dc.contributor.authorAbrahams, Sharon
dc.contributor.authorChandran, Siddharthan
dc.contributor.authorSmith, Colin
dc.contributor.authorGregory, Jenna
dc.date.accessioned2022-07-26T15:41:01Z
dc.date.available2022-07-26T15:41:01Z
dc.date.issued2020-01-31
dc.identifier217891942
dc.identifier4b623d1e-dfa5-4970-bec0-039688bcf7fc
dc.identifier85089840291
dc.identifier.citationMehta , A R , Barton , S K , McDade , K , Abrahams , S , Chandran , S , Smith , C & Gregory , J 2020 , ' Improved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction ' , Brain Communications , vol. 2 , no. 1 . https://doi.org/10.1093/braincomms/fcaa009en
dc.identifier.issn2632-1297
dc.identifier.otherORCID: /0000-0003-3337-4079/work/112144786
dc.identifier.urihttps://hdl.handle.net/2164/18932
dc.descriptionAcknowledgements The authors would like to thank: (i) the Medical Research Council Edinburgh Brain Bank (ethics approval from East of Scotland Research Ethics Service, 16/ES/0084)) for supplying all post-mortem brain material and the Scottish Motor Neurone Disease Register (SMNDR)/Care Audit Research and Evaluation for Motor Neurone Disease (CARE-MND) consortium for all clinical and demographic data (ethical approval from Scotland A Research Ethics Committee 10/MRE00/78 and 15/SS/0216); (ii) The Scottish MND Clinical Specialist team for obtaining consent from patients with MND for inclusion in these studies; (iii) MND Scotland and the Sylvia Aitken Charitable Trust for funding CS to help to establish the MND Tissue Bank. The authors would also like to thank Advanced Cell Diagnostics for gifting the C9orf72 probe (BaseScopeTM Probe - BA-GGGGCCn-3zz-st, Cat Code: 704181), prior to it being made commercially available. Funding A.R.M. is a Lady Edith Wolfson Clinical Fellow and is jointly funded by the Medical Research Council and the Motor Neurone Disease Association (MR/R001162/1). He also acknowledges support from the Rowling Scholars scheme, administered by the Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK. The Chandran laboratory is supported by the Euan MacDonald Centre and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. J.M.G. is funded by a starter grant for clinical lecturers from the Academy of Medical Sciences (AMS: 210JMG 3102 R45620) and C.S. is supported by a Medical Research Council grant (MR/L016400/1).en
dc.format.extent978195
dc.language.isoeng
dc.relation.ispartofBrain Communicationsen
dc.subjectsense RNA focien
dc.subjectcognitionen
dc.subjectTDP-43en
dc.subjectC9orf72en
dc.subjectALSen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/R001162/1en
dc.subjectMR/L016400/1en
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleImproved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunctionen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1093/braincomms/fcaa009
dc.identifier.urlhttp://dx.doi.org/10.1093/braincomms/fcaa009en
dc.identifier.vol2en
dc.identifier.iss1en


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