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The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1

dc.contributor.authorWhyte, Claire
dc.contributor.authorSimpson, Megan
dc.contributor.authorMorrow, Gael B
dc.contributor.authorWallace, Carol
dc.contributor.authorMentzer, Alexander J
dc.contributor.authorKnight, Julian C.
dc.contributor.authorShapiro, Susan
dc.contributor.authorCurry, Nicola
dc.contributor.authorBagot, Catherine N
dc.contributor.authorBagot, Catherine N
dc.contributor.authorWatson, Henry
dc.contributor.authorCooper, James
dc.contributor.authorMutch, Nicola
dc.date.accessioned2022-07-22T09:00:03Z
dc.date.available2022-07-22T09:00:03Z
dc.date.issued2022-09-19
dc.identifier217845542
dc.identifierdf006573-7787-41eb-97b5-e62ba7011f9b
dc.identifier35780481
dc.identifier85134536146
dc.identifier000855651500027
dc.identifier.citationWhyte , C , Simpson , M , Morrow , G B , Wallace , C , Mentzer , A J , Knight , J C , Shapiro , S , Curry , N , Bagot , C N , Bagot , C N , Watson , H , Cooper , J & Mutch , N 2022 , ' The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1 ' , Journal of Thrombosis and Haemostasis , vol. 20 , no. 10 , pp. 2394-2406 . https://doi.org/10.1111/jth.15806en
dc.identifier.issn1538-7933
dc.identifier.otherORCID: /0000-0001-9299-6754/work/116417850
dc.identifier.otherORCID: /0000-0001-8127-6102/work/116418568
dc.identifier.otherORCID: /0000-0002-3824-8808/work/117349608
dc.identifier.urihttps://hdl.handle.net/2164/18907
dc.descriptionAcknowledgements The authors would like to thank all the patients who consented to be part of this study, and all the staff at the Emergency Department of Aberdeen Royal Infirmary NHS Foundation Trust who looked after these patients, and the patients who consented. We thank the NHS Grampian Biorepository staff, Kristine Nellany, Nadine Hay and Joan Wilson for sample collection, processing and anonymisation and collation of clinical data. We acknowledge the Microscopy and Histology Core Facility and Dr Neil Scott from the Institute of Applied Health Sciences at the University of Aberdeen for excellent advice and use of the facilities. Funding This research was supported by NHS Grampian Endowment (COV19-004 and 20/021), Medical Research Scotland (CVG-1721-20), The University of Aberdeen Development Trust (RG15537), Friends of Anchor (RS 2019 003) and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. CSW and NJM are supported by the British Heart Foundation (PG/15/82/31721; PG/20/17/35050). JGC is supported by NHS Research Scotland. SS receives funding support from the Medical Research Council (MR/T024054/1).en
dc.format.extent13
dc.format.extent4629622
dc.language.isoeng
dc.relation.ispartofJournal of Thrombosis and Haemostasisen
dc.subjectCOVID-19en
dc.subjectFibrinen
dc.subjectFibrinolysisen
dc.subjectPAI-1en
dc.subjectVitronectinen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subjectPG/15/82/31721en
dc.subjectPG/20/17/35050en
dc.subjectOtheren
dc.subjectRS 2019 003en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/T024054/1en
dc.subject.lccRen
dc.titleThe suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1en
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1111/jth.15806
dc.identifier.vol20en
dc.identifier.iss10en


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