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Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

dc.contributor.authorJiwaji, Zoeb
dc.contributor.authorTiwari, Sachin S.
dc.contributor.authorAvilés-Reyes, Rolando X.
dc.contributor.authorHooley, Monique
dc.contributor.authorHampton, David
dc.contributor.authorTorvell, Megan
dc.contributor.authorJohnson, Delinda A.
dc.contributor.authorMcQueen, Jamie
dc.contributor.authorBaxter, Paul
dc.contributor.authorSabari-Sankar, Kayalvizhi
dc.contributor.authorQiu, Jing
dc.contributor.authorHe, Xin
dc.contributor.authorFowler, Jill
dc.contributor.authorFebery, James
dc.contributor.authorGregory, Jenna
dc.contributor.authorRose, Jamie
dc.contributor.authorTulloch, Jane
dc.contributor.authorLoan, Jamie
dc.contributor.authorStory, David
dc.contributor.authorMcDade, Karina
dc.contributor.authorSmith, Amy M.
dc.contributor.authorGreer, Peta
dc.contributor.authorBall, Matthew
dc.contributor.authorKind, Peter C.
dc.contributor.authorMatthews, Paul M.
dc.contributor.authorSmith, Colin
dc.contributor.authorDando, Owen
dc.contributor.authorSpires-Jones, Tara L.
dc.contributor.authorJohnson, Jeffrey A.
dc.contributor.authorChandran, Siddharthan
dc.contributor.authorHardingham, Giles E.
dc.date.accessioned2022-07-12T11:01:01Z
dc.date.available2022-07-12T11:01:01Z
dc.date.issued2022-01-10
dc.identifier217891444
dc.identifiercbcc6e5b-74be-4b42-a676-0f7a805d8047
dc.identifier85122865765
dc.identifier000798216000001
dc.identifier35013236
dc.identifier.citationJiwaji , Z , Tiwari , S S , Avilés-Reyes , R X , Hooley , M , Hampton , D , Torvell , M , Johnson , D A , McQueen , J , Baxter , P , Sabari-Sankar , K , Qiu , J , He , X , Fowler , J , Febery , J , Gregory , J , Rose , J , Tulloch , J , Loan , J , Story , D , McDade , K , Smith , A M , Greer , P , Ball , M , Kind , P C , Matthews , P M , Smith , C , Dando , O , Spires-Jones , T L , Johnson , J A , Chandran , S & Hardingham , G E 2022 , ' Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology ' , Nature Communications , vol. 13 , no. 1 , 135 . https://doi.org/10.1038/s41467-021-27702-wen
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0003-3337-4079/work/112143660
dc.identifier.otherMendeley: e7bc2cd7-6b2e-36ed-8351-e9b5c7a2cf52
dc.identifier.otherRIS: urn:6EF698C34D9A1FA455012EF46149EE13
dc.identifier.otherRIS: Jiwaji2022
dc.identifier.urihttps://hdl.handle.net/2164/18836
dc.descriptionFunding Information: We thank Michel Goedert for the MAPTP301S mouse and Nathaniel Heintz for the Aldh1l1_eGFP-RPL10a mouse. This work was funded by the UK Dementia Research Institute (G.E.H., S.C.) which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society, and Alzheimer’s Research UK, the European Research Council (ERC) under the EU’s Horizon 2020 research and innovation programme (Grant No. 681181, T.S.J.) and grant NIH P50 AG033514 (Project 1, J.A.J.).en
dc.format.extent23
dc.format.extent8245417
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAlzheimer Disease/geneticsen
dc.subjectAmyloid beta-Protein Precursor/geneticsen
dc.subjectAnimalsen
dc.subjectAstrocytes/cytologyen
dc.subjectBrain/metabolismen
dc.subjectDisease Models, Animalen
dc.subjectFemaleen
dc.subjectGene Expression Profilingen
dc.subjectGene Expression Regulationen
dc.subjectHomozygoteen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Transgenicen
dc.subjectNF-E2-Related Factor 2/geneticsen
dc.subjectNeuroprotection/geneticsen
dc.subjectPhenotypeen
dc.subjectPhosphorylationen
dc.subjectProteostasis/geneticsen
dc.subjectProto-Oncogene Proteins/geneticsen
dc.subjectSignal Transductionen
dc.subjectTrans-Activators/geneticsen
dc.subjecttau Proteins/geneticsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectGeneral Physics and Astronomyen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectAlzheimers Research UKen
dc.subjectEuropean Research Councilen
dc.subject681181, T.S.J.en
dc.subjectNIH P50 AG033514en
dc.subjectSupplementary Informationen
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleReactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathologyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1038/s41467-021-27702-w
dc.identifier.urlhttp://dx.doi.org/10.1038/s41467-021-27702-wen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85122865765&partnerID=8YFLogxKen
dc.identifier.urlhttps://www.mendeley.com/catalogue/e7bc2cd7-6b2e-36ed-8351-e9b5c7a2cf52/en


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