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Probing TDP-43 condensation using an in silico designed aptamer

dc.contributor.authorZacco, Elsa
dc.contributor.authorKantelberg, Owen
dc.contributor.authorMilanetti, Edoardo
dc.contributor.authorArmaos, Alexandros
dc.contributor.authorPanei, Francesco Paolo
dc.contributor.authorGregory, Jenna
dc.contributor.authorJeacock, Kiani
dc.contributor.authorClarke, David J.
dc.contributor.authorChandran, Siddharthan
dc.contributor.authorRuocco, Giancarlo
dc.contributor.authorGustincich, Stefano
dc.contributor.authorHorrocks, Mathew
dc.contributor.authorPastore, Annalisa
dc.contributor.authorTartaglia, Gian Gaetano
dc.date.accessioned2022-07-08T16:18:01Z
dc.date.available2022-07-08T16:18:01Z
dc.date.issued2022-06-23
dc.identifier217891202
dc.identifier8b266379-c0a2-4c98-a03d-8574b6e7682d
dc.identifier85132547899
dc.identifier.citationZacco , E , Kantelberg , O , Milanetti , E , Armaos , A , Panei , F P , Gregory , J , Jeacock , K , Clarke , D J , Chandran , S , Ruocco , G , Gustincich , S , Horrocks , M , Pastore , A & Tartaglia , G G 2022 , ' Probing TDP-43 condensation using an in silico designed aptamer ' , Nature Communications , vol. 13 , 3306 . https://doi.org/10.1038/s41467-022-30944-xen
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0003-3337-4079/work/114913516
dc.identifier.urihttps://hdl.handle.net/2164/18829
dc.descriptionWe thank the “RNA Initiative” at IIT, all members of the M.H.H., A.P., and G.G.T. groups, and especially Fernando Cid Samper. M.H.H. wishes to thank UCB Biopharma and Dr Jim Love for providing funding for the instrument used to generate the super-resolution data in this manuscript. A.P. acknowledges funding from UK DRI (grant REI 3556) and AlzheimerUK (grant ARUK-PG2019B-020). O.K. was supported by a Scottish PhD Research & Innovation Network Traineeships in MND/MS. E.Z. received funding from the Newton fellowship scheme and the MINDED fellowship of the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 754490. K.J. was funded via the BBSRCEastBIO doctoral training program (BB/M010996/1). The research leading to these results was supported by European Research Council [RIBOMYLOME n. 309545 to G.G.T. and ASTRA n. 855923 to G.G.T.], H2020 [IASIS n. 727658 to G.G.T. and INFORE n. 825080 to G.G.T.] and MND [840-791 to G.G.T. and A.P.] projects. The authors would also like to acknowledge the help and support received during confocal images acquisition by the group of Giuseppe Vicidomini at the Molecular Microscopy and Spectroscopy Department of IIT.en
dc.format.extent13
dc.format.extent5133465
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectcomputational modelsen
dc.subjectRNAen
dc.subjectRNA-Binding Proteinsen
dc.subjectSuper-resolution microscopyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectOtheren
dc.subjectUK DRI grant REI 3556en
dc.subjectAlzheimers Research UKen
dc.subjectARUK-PG2019B-020en
dc.subjectEuropean Research Councilen
dc.subjectRIBOMYLOME n. 309545en
dc.subjectASTRA n. 855923en
dc.subject.lccRC0321en
dc.titleProbing TDP-43 condensation using an in silico designed aptameren
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1038/s41467-022-30944-x
dc.identifier.urlhttp://dx.doi.org/10.1038/s41467-022-30944-xen
dc.identifier.vol13en


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