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Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

dc.contributor.authorMehta, Arpan R.
dc.contributor.authorGregory, Jenna
dc.contributor.authorDando, Owen
dc.contributor.authorCarter, Roderick N.
dc.contributor.authorBurr, Karen
dc.contributor.authorNanda, Jyoti
dc.contributor.authorStory, David
dc.contributor.authorMcDade, Karina
dc.contributor.authorSmith, Colin
dc.contributor.authorMorton, Nicholas M.
dc.contributor.authorMahad, Don J.
dc.contributor.authorHardingham, Giles E.
dc.contributor.authorChandran, Siddharthan
dc.contributor.authorSelvaraj, Bhuvaneish T.
dc.date.accessioned2022-07-06T15:56:01Z
dc.date.available2022-07-06T15:56:01Z
dc.date.issued2021-02
dc.identifier217891560
dc.identifier32fb4e64-13e3-4cec-8966-4f963f66c626
dc.identifier85098664713
dc.identifier.citationMehta , A R , Gregory , J , Dando , O , Carter , R N , Burr , K , Nanda , J , Story , D , McDade , K , Smith , C , Morton , N M , Mahad , D J , Hardingham , G E , Chandran , S & Selvaraj , B T 2021 , ' Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis ' , Acta Neuropathologica , vol. 141 , pp. 257-279 . https://doi.org/10.1007/s00401-020-02252-5en
dc.identifier.issn0001-6322
dc.identifier.otherORCID: /0000-0003-3337-4079/work/112144154
dc.identifier.urihttps://hdl.handle.net/2164/18808
dc.descriptionARM is a Lady Edith Wolfson Clinical Fellow and is jointly funded by the Medical Research Council (MRC) and the Motor Neurone Disease Association (MR/R001162/1). He also acknowledges support from the Rowling Scholars scheme, administered by the Anne Rowling Regenerative Neurology Clinic (ARRNC), University of Edinburgh, and a seedcorn grant from The Chief Scientist Office and the RS Macdonald Charitable Trust via the Scottish Neurological Research Fund, administered by the University of St Andrews. JMG is funded by a starter grant for clinical lecturers from the Academy of Medical Sciences. CS is supported by a Medical Research Council grant (MR/L016400/1). NMM was funded by a Wellcome Trust New Investigator Award (100981/Z/13/Z). RNC and NMM are funded by a Diabetes UK grant (17/0005697). The Hardingham and Chandran laboratories are supported by the Euan MacDonald Centre for Motor Neurone Disease Research, and the UK Dementia Research Institute (DRI), which receives its funding from UK DRI Ltd, funded by the MRC, Alzheimer's Society and Alzheimer's Research UK. SC also acknowledges funding from the ARRNC, My Name’5 Doddie Foundation, and an MRC Dementias Platform UK Stem Cell Partnership grant (MR/N013255/1). BTS is a Rowling-DRI Fellow.en
dc.format.extent12
dc.format.extent6099258
dc.language.isoeng
dc.relation.ispartofActa Neuropathologicaen
dc.subjectAmyotrophic lateral sclerosisen
dc.subjectAxonen
dc.subjectEnergy metabolismen
dc.subjectFrontotemporal dementiaen
dc.subjectMitochondriaen
dc.subjectMotor neuronen
dc.subjectNeurodegenerationen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/R001162/1en
dc.subjectMR/L016400/1en
dc.subjectWellcome Trusten
dc.subject100981/Z/13/Zen
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleMitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1007/s00401-020-02252-5
dc.identifier.urlhttp://dx.doi.org/10.1007/s00401-020-02252-5en
dc.identifier.vol141en


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