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Effect of perindopril or leucine on physical performance in older people with sarcopenia : the LACE randomized controlled trial

dc.contributor.authorAchison, Marcus
dc.contributor.authorAdamson, Simon
dc.contributor.authorAkpan, Asangaedem
dc.contributor.authorAspray, Terry
dc.contributor.authorAvenell, Alison
dc.contributor.authorBand, Margaret M.
dc.contributor.authorBashir, Tufail
dc.contributor.authorBurton, Louise A.
dc.contributor.authorCvoro, Vera
dc.contributor.authorDonnan, Peter T.
dc.contributor.authorDuncan, Gordon W.
dc.contributor.authorGeorge, Jacob
dc.contributor.authorGordon, Adam L.
dc.contributor.authorGregson, Celia L.
dc.contributor.authorHapca, Adrian
dc.contributor.authorHenderson, Emily
dc.contributor.authorHume, Cheryl
dc.contributor.authorJackson, Thomas A.
dc.contributor.authorKemp, Paul
dc.contributor.authorKerr, Simon
dc.contributor.authorKilgour, Alixe
dc.contributor.authorLyell, Veronica
dc.contributor.authorMasud, Tahir
dc.contributor.authorMcKenzie, Andrew
dc.contributor.authorMcKenzie, Emma
dc.contributor.authorPatel, Harnish
dc.contributor.authorPilvinyte, Kristina
dc.contributor.authorRoberts, Helen C.
dc.contributor.authorRossios, Christos
dc.contributor.authorSayer, Avan A.
dc.contributor.authorSmith, Karen T.
dc.contributor.authorSoiza, Roy L.
dc.contributor.authorSteves, Claire J.
dc.contributor.authorStruthers, Allan D.
dc.contributor.authorSumukadas, Deepa
dc.contributor.authorTiwari, Divya
dc.contributor.authorWhitney, Julie
dc.contributor.authorWitham, Miles D.
dc.contributor.authorLACE study group
dc.date.accessioned2022-06-16T16:04:01Z
dc.date.available2022-06-16T16:04:01Z
dc.date.issued2022-04-01
dc.identifier211923152
dc.identifier97d743f0-4122-4929-941c-ea4829460c5e
dc.identifier85128160996
dc.identifier000756067200001
dc.identifier85128160996
dc.identifier35174663
dc.identifier.citationAchison , M , Adamson , S , Akpan , A , Aspray , T , Avenell , A , Band , M M , Bashir , T , Burton , L A , Cvoro , V , Donnan , P T , Duncan , G W , George , J , Gordon , A L , Gregson , C L , Hapca , A , Henderson , E , Hume , C , Jackson , T A , Kemp , P , Kerr , S , Kilgour , A , Lyell , V , Masud , T , McKenzie , A , McKenzie , E , Patel , H , Pilvinyte , K , Roberts , H C , Rossios , C , Sayer , A A , Smith , K T , Soiza , R L , Steves , C J , Struthers , A D , Sumukadas , D , Tiwari , D , Whitney , J , Witham , M D & LACE study group 2022 , ' Effect of perindopril or leucine on physical performance in older people with sarcopenia : the LACE randomized controlled trial ' , Journal of Cachexia, Sarcopenia and Muscle , vol. 13 , no. 2 , pp. 858-871 . https://doi.org/10.1002/jcsm.12934en
dc.identifier.issn2190-6009
dc.identifier.otherORCID: /0000-0002-1397-4272/work/115134605
dc.identifier.urihttps://hdl.handle.net/2164/18718
dc.descriptionAcknowledgements: AAS, TA and MDW acknowledge support from the NIHR Newcastle Biomedical Research Centre. AA acknowledges support from the Health Services Research Unit which is core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorate. The authors acknowledge support from the NIHR Ageing Clinical Research Network and the NHS Scotland Support for Science programme, The authors would also thank the efforts of all the research nurses and other ants to the trial, all the participants, and all the staff of the Tayside Clinical Trials Unit for their support of the trial. Funding: The LACE trial (project reference 13/53/03) is funded by the Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR partnership. The views expressed in this publication are those of the authors and not necessarily those of the MRC, NIHR or the Department of Health and Social Care.en
dc.format.extent14
dc.format.extent1075988
dc.language.isoeng
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Muscleen
dc.subjectAngiotensin converting enzyme inhibitoren
dc.subjectLeucineen
dc.subjectSarcopeniaen
dc.subjectRandomised Controlled Triaen
dc.subjectMeta-Analysis as Topicen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectTreatment Outcomeen
dc.subjectPerindopril/therapeutic useen
dc.subjectSarcopenia/drug therapyen
dc.subjectHand Strength/physiologyen
dc.subjectFemaleen
dc.subjectAgeden
dc.subjectPhysical Functional Performanceen
dc.subjectLeucine/therapeutic useen
dc.subjectPREVALENCEen
dc.subjectSUPPLEMENTATIONen
dc.subjectINTERVENTIONSen
dc.subjectBIOELECTRICAL-IMPEDANCE ANALYSISen
dc.subjectSKELETAL-MUSCLE MASSen
dc.subjectADULTSen
dc.subjectELDERLY-PEOPLEen
dc.subjectLOWER-EXTREMITY FUNCTIONen
dc.subjectRandomized controlled trialen
dc.subjectDOUBLE-BLINDen
dc.subjectASSOCIATIONen
dc.subjectR Medicineen
dc.subjectPhysiology (medical)en
dc.subjectOrthopedics and Sports Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subject13/53/03en
dc.subjectChief Scientist Office (CSO)en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectSupplementary Dataen
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleEffect of perindopril or leucine on physical performance in older people with sarcopenia : the LACE randomized controlled trialen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Health Services Research Uniten
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.identifier.doi10.1002/jcsm.12934
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85128160996&partnerID=8YFLogxKen


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