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Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis

dc.contributor.authorSymons, Rebecca A.
dc.contributor.authorColella, Fabio
dc.contributor.authorCollins, Fraser L.
dc.contributor.authorRafipay, Alexandra J.
dc.contributor.authorKania, Karolina
dc.contributor.authorMcClure, Jessica J.
dc.contributor.authorWhite, Nathan
dc.contributor.authorCunningham, Iain
dc.contributor.authorAshraf, Sadaf
dc.contributor.authorHay, Elizabeth
dc.contributor.authorMackenzie, Kevin S.
dc.contributor.authorHoward, Kenneth A.
dc.contributor.authorRiemen, Anna H. K.
dc.contributor.authorManzo, Antonio
dc.contributor.authorClark, Susan M.
dc.contributor.authorRoelofs, Anke J.
dc.contributor.authorDe Bari, Cosimo
dc.date.accessioned2022-04-13T16:45:01Z
dc.date.available2022-04-13T16:45:01Z
dc.date.issued2022-02
dc.identifier201503244
dc.identifier153ccb36-4f0e-483f-8673-d590631f6734
dc.identifier000724317200001
dc.identifier000724317200001
dc.identifier85123651848
dc.identifier85123651848
dc.identifier34844926
dc.identifier.citationSymons , R A , Colella , F , Collins , F L , Rafipay , A J , Kania , K , McClure , J J , White , N , Cunningham , I , Ashraf , S , Hay , E , Mackenzie , K S , Howard , K A , Riemen , A H K , Manzo , A , Clark , S M , Roelofs , A J & De Bari , C 2022 , ' Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis ' , Annals of the Rheumatic Diseases , vol. 81 , no. 2 , pp. 214-224 . https://doi.org/10.1136/annrheumdis-2021-220875en
dc.identifier.issn0003-4967
dc.identifier.otherORCID: /0000-0002-1156-6873/work/111707768
dc.identifier.otherORCID: /0000-0002-0041-5375/work/111708131
dc.identifier.otherMendeley: dcf71690-7bf7-3edb-b6e4-90d3ed1b058e
dc.identifier.otherORCID: /0000-0002-2811-7919/work/127304773
dc.identifier.urihttps://hdl.handle.net/2164/18411
dc.descriptionACKNOWLEDGEMENTS The authors thank staff at the University of Aberdeen’s Animal Facility, Microscopy and Histology Facility, qPCR Facility, and the Iain Fraser Cytometry Centre for their expert support. The authors also thank the NHS Grampian Biorepository for facilitating the collection of human tissue samples. Additionally, thanks is given to Denis Evseenko for critical review of the manuscript. Funding This work was supported by funding from the Medical Research Council (grants MR/L020211/1, MR/L022893/1), Versus Arthritis (formerly Arthritis Research UK, grants 20775, 19429, 21156, 20050, 19667, 20865, 21800), Tenovus Scotland (grant G13/14), and European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska Curie (Grant 642414).en
dc.format.extent11
dc.format.extent15004775
dc.language.isoeng
dc.relation.ispartofAnnals of the Rheumatic Diseasesen
dc.subjectarthritisen
dc.subjectexperimentalen
dc.subjectrheumatoiden
dc.subjectfibroblastsen
dc.subjectinflammationen
dc.subjectCELLSen
dc.subjectGROWTHen
dc.subjectINHIBITIONen
dc.subjectEXPRESSIONen
dc.subjectSURVIVALen
dc.subjectCATENINen
dc.subjectYAP/TAZen
dc.subjectJOINTen
dc.subjectSIZEen
dc.subjectHumansen
dc.subjectSignal Transduction/physiologyen
dc.subjectFibroblasts/metabolismen
dc.subjectSynovial Membrane/metabolismen
dc.subjectCells, Cultureden
dc.subjectSnail Family Transcription Factors/metabolismen
dc.subjectYAP-Signaling Proteins/metabolismen
dc.subjectArthritis, Experimental/pathologyen
dc.subjectAnimalsen
dc.subjectInterleukin-6/metabolismen
dc.subjectMiceen
dc.subjectArthritis, Rheumatoid/metabolismen
dc.subjectR Medicineen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectRheumatologyen
dc.subjectImmunology and Allergyen
dc.subjectImmunologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/L020211/1en
dc.subjectMR/L022893/1en
dc.subjectOtheren
dc.subjectG13/14en
dc.subjectArthritis Research UK (ARUK)en
dc.subject20775en
dc.subject19429en
dc.subject21156en
dc.subject20050en
dc.subject19667en
dc.subject20865en
dc.subject21800en
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleTargeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.description.statusPeer revieweden
dc.identifier.doi10.1136/annrheumdis-2021-220875
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85123651848&partnerID=8YFLogxKen
dc.identifier.urlhttps://www.mendeley.com/catalogue/dcf71690-7bf7-3edb-b6e4-90d3ed1b058e/en


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