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      Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery

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      Cuthbertson B.H 2007.pdf (211.6Kb)
      Publication date
      2007
      Author
      Cuthbertson, Brian
      Amiri, Amir R.
      Croal, Bernard L.
      Rajagopalan, Sriram
      Brittenden, Julie
      Hillis, Graham S.
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      Abstract
      We assessed the ability of pre-operative B-type natriuretic peptide (BNP) levels to predict medium-term mortality in patients undergoing major noncardiac surgery. During a median 654 days follow-up 33 patients from a total cohort of 204 patients (16%) died. The optimal cut-off in this cohort, determined using a receiver operating characteristic curve, was >35pg.mL-1. This was associated with a 3.47-fold increase in the hazard of death (p=0.001) and had a sensitivity of 70% and a specificity of 68% for this outcome. These findings extend recent work demonstrating that BNP levels obtained before major noncardiac surgery can be used to predict peri-operative morbidity, and indicate that they also forecast medium-term mortality.
      Citation
      Cuthbertson, B.H., Amiri, A.R., Croal, B.L., Rajagopalan, S., Brittennden, J., and Hillis, G.S. (2007). Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery. American Journal of Cardiology, 100(8), pp.1310-1313.
      URI
      http://hdl.handle.net/2164/171
      DOI
      http://dx.doi.org/10.1016/j.amjcard.2007.05.058
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