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Surgical Treatment for Recurrent Bulbar Urethral Stricture : A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)

dc.contributor.authorGoulao, Beatriz
dc.contributor.authorCarnell, Sonya
dc.contributor.authorShen, Jing
dc.contributor.authorMacLennan, Graeme
dc.contributor.authorNorrie, John
dc.contributor.authorCook, Jonathan
dc.contributor.authorMcColl, Elaine
dc.contributor.authorBreckons, Matthew
dc.contributor.authorVale, Luke
dc.contributor.authorWhybrow, Paul
dc.contributor.authorRapley, Tim
dc.contributor.authorForbes, Rebecca
dc.contributor.authorCurrer, Stephanie
dc.contributor.authorForrest, Mark
dc.contributor.authorWilkinson, Jennifer
dc.contributor.authorAndrich, Daniela
dc.contributor.authorBarclay, Stewart
dc.contributor.authorMundy, Anthony
dc.contributor.authorN'Dow, James
dc.contributor.authorPayne, Stephen
dc.contributor.authorWatkin, Nick
dc.contributor.authorPickard, Robert
dc.date.accessioned2021-07-03T23:08:38Z
dc.date.available2021-07-03T23:08:38Z
dc.date.issued2020-10
dc.identifier171681166
dc.identifier1ebbb7ee-e815-4d6c-b628-35154a609f35
dc.identifier85087389807
dc.identifier32636099
dc.identifier000572637700028
dc.identifier.citationGoulao , B , Carnell , S , Shen , J , MacLennan , G , Norrie , J , Cook , J , McColl , E , Breckons , M , Vale , L , Whybrow , P , Rapley , T , Forbes , R , Currer , S , Forrest , M , Wilkinson , J , Andrich , D , Barclay , S , Mundy , A , N'Dow , J , Payne , S , Watkin , N & Pickard , R 2020 , ' Surgical Treatment for Recurrent Bulbar Urethral Stricture : A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial) ' , European Urology , vol. 78 , no. 4 , pp. 572-580 . https://doi.org/10.1016/j.eururo.2020.06.003en
dc.identifier.issn0302-2838
dc.identifier.otherORCID: /0000-0002-1039-5646/work/98038510
dc.identifier.urihttps://hdl.handle.net/2164/16774
dc.descriptionFunding/Support and role of the sponsor: This work was supported by the Newcastle University Hospitals NHS Foundation Trust for Research Governance, and funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme Clinical Evaluation and Trials Panel (trial registration ISRCTN: 98009168). Acknowledgements: We thank the patients and health care professionals for their participation in qualitative interviews. We also thank Stewart Barclay, the patient and service user representative on the OPEN Trial Management Group. We acknowledge the Trial Steering Committee members: Roger Kockelburg (Chair), John Matthews, Alan McNeil, Howard Kynaston, Neil Campling. Data Monitoring Committee members: Gordon Murray (Chair), Richard Martin, and Thomas Pinkney. We thank Matthew Jackson (research fellow), Gladys McPherson (data manager), Lee Munro (trial manager), Rachel Stephenson (trial manager), Sue Tremble (trial manager), Robbie Brown (trial manager), Mark Deverill (health economist), Amy Collins (project secretary), Lavinia Miceli (project secretary), and Ann Payne (project secretary). Sarah Hill and David Mott contributed to the development and interviews of the TTO exercise, and Joanne O’Connor and Beena David contributed to the interviews of the TTO exercise. Assistance was provided by Peter Murphy and Wendy Robson when conducting TTO pilots in Freeman Hospital. All the volunteers who took part in the TTO pilots and participants in TTO interviews are acknowledged. The following sites and Principal Investigators are acknowledged for their support: Mr. Trevor Dorkin, Freeman Hospital, Newcastle; Professor Nick Watkin, St George's Hospital, London; Professor Anthony Mundy, University College London Hospitals; Mr. Paul Anderson, Russells Hall Hospital, Dudley; Mrs. Suzie Venn, Queen Alexandra Hospital, Portsmouth; Mr. Ian Eardley, St James University Hospital, Leeds; Mr. David Dickerson, Weston General Hospital; Mr. Nikesh Thiruchelvam, Addenbrooke's Hospital, Cambridge; Mr. Richard Inman and Mr. Chris Chapple, Royal Hallamshire Hospital, Sheffield; Mr. Andrew Baird, University Hospital, Aintree; Mr. Andrew Sinclair, Stepping Hill Hospital; Mr. Rajeshwar Krishnanm, Kent and Canterbury Hospital; Mr. Rowland Rees, University Hospital, Southampton; Professor James N'dow, Aberdeen Royal Infirmary; Mr. Bruce Montgomery, Frimley Park Hospital, Camberley; Mr. Michael Swinn, East Surrey Hospital; Mr. Alastair Henderson, Mr. John Donohue, Maidstone Hospital; Mrs. Suzie Venn, St Richards Hospital, Chichester; Mr. Robert Mason, Torbay Hospital; Mr. Sanjeev Madaan, Darent Valley Hospital; Mr. Mustafa Hilmy, York Hospital; Miss Vivienne Kirchin, Sunderland Royal Infirmary; Kim Davenport, Cheltenham General Hospital; John McGrath, Exeter Hospital; Tim Porter, Yeovil District Hospital; RuaraidhvMacDonagh, Amerdip Birring, Musgrove Park, Taunton; Ramachandran Ravi, Basildon; Jawad Husain, Wigan; Maj Shabbir, Guy's Hospital; Omer Baldo, Airedale Hospital; Sadhanshu Chitale, Whittington Hospital; Mary Garthwaite, James Cook University Hospital; Shalom Srirangam, Royal Blackburn Hospital; Liaqat Chowoo, Bedford Hospital; Tina Rashid, Charing Cross; Rob Skyrme; Jon Featherstone, Princess of Wales Hospital, Bridgend; and Mr. Ammar Alhasso, Edinburgh; Mr Oleg Tatarov, Cardiff. We thank the following trusts for offering PIC support: Basingstoke and Northamptonshire NHS Foundation Trust; Royal Liverpool and Broadgreen University Hospitals NHS Trust; Chelsea and Westminster NHS Foundation Trust; and Wirral University Teaching Hospitals NHS Foundation Trust.en
dc.format.extent9
dc.format.extent1163878
dc.language.isoeng
dc.relation.ispartofEuropean Urologyen
dc.subjectSurgeryen
dc.subjectRandmised controlled trialen
dc.subjectUrethral strictureen
dc.subjectUrethroplastyen
dc.subjectUrethrotomyen
dc.subjectVoiding sympstomsen
dc.subjectVoiding symptomsen
dc.subjectRandomised controlled trialen
dc.subjectINTERNAL URETHROTOMYen
dc.subjectMANAGEMENTen
dc.subjectSIU/ICUD CONSULTATIONen
dc.subjectDILATIONen
dc.subjectR Medicineen
dc.subjectUrologyen
dc.subjectOtheren
dc.subjectNational Institute for Health Research (NIHR)en
dc.subject.lccRen
dc.titleSurgical Treatment for Recurrent Bulbar Urethral Stricture : A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)en
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Health Services Research Uniten
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Academic Urology Uniten
dc.description.statusPeer revieweden
dc.identifier.doi10.1016/j.eururo.2020.06.003
dc.date.embargoedUntil2021-07-04
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85087389807&partnerID=8YFLogxKen


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