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Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs

dc.contributor.authorAztekin, C.
dc.contributor.authorHiscock, Tom W.
dc.contributor.authorGurdon, John
dc.contributor.authorJullien, Jerome
dc.contributor.authorMarioni, John C.
dc.contributor.authorSimons, Benjamin David
dc.date.accessioned2021-06-14T15:25:01Z
dc.date.available2021-06-14T15:25:01Z
dc.date.issued2021-06-30
dc.identifier193172668
dc.identifierde22d816-99cb-45f2-b2ac-1bb9bc37e37b
dc.identifier34105722
dc.identifier85108012996
dc.identifier.citationAztekin , C , Hiscock , T W , Gurdon , J , Jullien , J , Marioni , J C & Simons , B D 2021 , ' Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs ' , Development , vol. 148 , no. 11 , dev199158. https://doi.org/10.1242/dev.199158en
dc.identifier.issn0950-1991
dc.identifier.otherORCID: /0000-0002-0319-8679/work/95222803
dc.identifier.urihttps://hdl.handle.net/2164/16667
dc.descriptionACKNOWLEDGEMENTS We thank Katarzyna Kania and the Cambridge Institute Genomics Core for their support with this work on the 10X-Genomics and sequencing library preparations. The transgenic testes used in this study was obtained from the European Xenopus Resource Centre, curated with funding from the Wellcome Trust/BBSRC, and maintained by the University of Portsmouth, School of Biological Sciences. We thank R. Jones-Green for excellent animal care. We thank H. Ma for use of her stereomicroscope, and E. Rawlins for use of her Zeiss Axiolmager compound microscope. We thank B. Steventon, E. Rawlins, and members of the Marioni and Simons labs for general discussion about the project. We thank R. Butler for assistance in image analysis. FUNDING C.A. is funded by University of Cambridge and Cambridge Trust. J.J. and J.B.G. are funded by a grant from the Wellcome Trust (101050/Z/13/Z). T.W.H., J.C.M., and B.D.S. are funded as part of a Wellcome Strategic Award to study cell fate decisions (105031/D/14/Z). T.W.H. is also supported by an EMBO Long-Term Fellowship (ALTF 606-2018). B.D.S. also acknowledges funding from the Royal Society E.P. Abraham Research Professorship (RP\R1\180165) and Wellcome Trust (098357/Z/12/Z). J.C.M. acknowledges core funding from the European Molecular Biology Laboratory and Cancer Research UK (A17197). This work is funded by a grant from the Wellcome Trust (101050/Z/13/Z), Molecular Research Council (MR/P000479/1), and supported by the Gurdon Institute core grant from Cancer Research UK (C6946/A14492) and the Wellcome Trust (092096/Z/10/Z).en
dc.format.extent39
dc.format.extent9160292
dc.language.isoeng
dc.relation.ispartofDevelopmenten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectLimb regenerationen
dc.subjectEx vivo limbsen
dc.subjectScRNA-Seqen
dc.subjectApical-ectodermal-ridgeen
dc.subjectXenopusen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject101050/Z/13/Zen
dc.subject105031/D/14/Zen
dc.subject098357/Z/12/Zen
dc.subject092096/Z/10/Zen
dc.subjectCancer Research UKen
dc.subjectA17197en
dc.subjectC6946/A14492en
dc.subjectOtheren
dc.subjectRP\R1\180165en
dc.subjectALTF 606-2018en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/P000479/1en
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleSecreted inhibitors drive the loss of regeneration competence in Xenopus limbsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1242/dev.199158


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