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Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease

dc.contributor.authorMaple-Grødem, Jodi
dc.contributor.authorDalen, Ingvild
dc.contributor.authorTysnes, Ole-Bjorn
dc.contributor.authorMacLeod, Angus Donald
dc.contributor.authorForsgren, Lars
dc.contributor.authorCounsell, Carl Edward
dc.contributor.authorAlves, Guido
dc.date.accessioned2021-03-08T15:11:01Z
dc.date.available2021-03-08T15:11:01Z
dc.date.issued2021-02-16
dc.identifier177883915
dc.identifier788c5446-ebce-41ab-af87-5a37164af066
dc.identifier33443131
dc.identifier85102153745
dc.identifier000656635000022
dc.identifier.citationMaple-Grødem , J , Dalen , I , Tysnes , O-B , MacLeod , A D , Forsgren , L , Counsell , C E & Alves , G 2021 , ' Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease ' , Neurology , vol. 96 , no. 7 , pp. e1036-e1044 . https://doi.org/10.1212/WNL.0000000000011411en
dc.identifier.issn0028-3878
dc.identifier.otherORCID: 0000-0002-6284-4239
dc.identifier.otherORCID: 0000-0001-6622-7839
dc.identifier.urihttps://hdl.handle.net/2164/15994
dc.descriptionStudy Funding The Norwegian ParkWest study has been funded by the Research Council of Norway (grant 177966) and the Western Norway Regional Health Authority (grant 911218) and the Norwegian Parkinsons Disease Association. J.M.-G. and G.A. are supported by the Research Council of Norway (grant 287842). PINE was supported by Parkinson’s UK (grants G0502, G0914, and G1302), Scottish Government Chief Scientist Office, BMA Doris Hillier Award, the BUPA Foundation, NHS Grampian Endowments, and RS MacDonald Trust. The NYPUM study has been funded by the Swedish Medical Research Council, the Swedish Parkinson’s Disease Association, the Swedish Parkinson Foundation, and the Västerbotten County Council. Disclosure J. Maple-Grødem, I. Dalen, and O.-B. Tysnes report no disclosures relevant to the manuscript. A. Macleod reports fellowship funding from the Scottish Chief Scientist Office (PCL/17/10) and grant funding from the Academy of Medical Sciences and NHS Grampian Endowments. L. Forsgren reports no disclosures relevant to the manuscript. C. Counsell reports NHS Grampian Endowments and RS Macdonald Trust. G. Alves reports Norwegian Research Council grant 287842, principal investigator, 2019–2022 and support from University of Stavanger, Norwegian Parkinson Research Foundation, and Reberg's Legacy. Go to Neurology.org/N for full disclosures. Acknowledgment The authors thank the patients for participating in the studies; ParkWest thanks all members of the Norwegian ParkWest study group and other personnel involved in the study; NYPUM thanks the study nurse/coordinator Mona Edström and laboratory technician Jörgen Andersson for database management; and PINE thanks the research fellows (Kate Taylor, Robert Caslake, and David McGhee) and study nurses (Clare Harris, Joanna Gordon, Anne Hayman, and Hazel Forbes) who assessed participants, the secretaries (Susan Kilpatrick and Pam Rebecca), the data management team (Katie Wilde and David Ritchie), and the clinicians who referred patients to the PINE study.en
dc.format.extent9
dc.format.extent383302
dc.language.isoeng
dc.relation.ispartofNeurologyen
dc.subjectActivities of Daily Livingen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectGlucosylceramidase/geneticsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMental Status and Dementia Testsen
dc.subjectMiddle Ageden
dc.subjectMutationen
dc.subjectParkinson Disease/geneticsen
dc.subjectR Medicineen
dc.subjectClinical Neurologyen
dc.subjectParkinson's UKen
dc.subjectG0502en
dc.subjectG0914en
dc.subjectG1302en
dc.subject.lccRen
dc.titleAssociation of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Diseaseen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Chronic Disease Research Groupen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1212/WNL.0000000000011411
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85102153745&partnerID=8YFLogxKen
dc.identifier.vol96en
dc.identifier.iss7en


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