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Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder

dc.contributor.authorGreen, Claire
dc.contributor.authorShen, Xueyi
dc.contributor.authorStevenson, Anna J.
dc.contributor.authorConole, Eleanor L.S.
dc.contributor.authorHarris, Mathew A.
dc.contributor.authorBarbu, Miruna C.
dc.contributor.authorHawkins, Emma L.
dc.contributor.authorAdams, Mark J.
dc.contributor.authorHillary, Robert F.
dc.contributor.authorLawrie, Stephen M.
dc.contributor.authorEvans, Kathryn L.
dc.contributor.authorWalker, Rosie M.
dc.contributor.authorMorris, Stewart W.
dc.contributor.authorPorteous, David J.
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorSteele, J. Douglas
dc.contributor.authorWaiter, Gordon D.
dc.contributor.authorSandu, Anca Larisa
dc.contributor.authorCampbell, Archie
dc.contributor.authorMarioni, Riccardo E.
dc.contributor.authorCox, Simon R.
dc.contributor.authorCavanagh, Jonathan
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorWhalley, Heather C.
dc.date.accessioned2021-01-12T18:10:08Z
dc.date.available2021-01-12T18:10:08Z
dc.date.issued2021-02-01
dc.identifier185484702
dc.identifier04997766-db78-41d8-9eb2-1ef9693056e0
dc.identifier85097058647
dc.identifier33221487
dc.identifier.citationGreen , C , Shen , X , Stevenson , A J , Conole , E L S , Harris , M A , Barbu , M C , Hawkins , E L , Adams , M J , Hillary , R F , Lawrie , S M , Evans , K L , Walker , R M , Morris , S W , Porteous , D J , Wardlaw , J M , Steele , J D , Waiter , G D , Sandu , A L , Campbell , A , Marioni , R E , Cox , S R , Cavanagh , J , McIntosh , A M & Whalley , H C 2021 , ' Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder ' , Brain, Behavior, and Immunity , vol. 92 , pp. 39-48 . https://doi.org/10.1016/j.bbi.2020.11.024en
dc.identifier.issn0889-1591
dc.identifier.otherORCID: 0000-0002-5313-9845
dc.identifier.otherORCID: 0000-0002-5555-4129
dc.identifier.otherORCID: 0000-0002-0538-4774
dc.identifier.otherORCID: 0000-0002-0435-3562
dc.identifier.otherORCID: 0000-0001-8967-683X
dc.identifier.otherORCID: 0000-0002-2595-552X
dc.identifier.otherORCID: 0000-0002-7884-5877
dc.identifier.otherORCID: 0000-0003-1249-6106
dc.identifier.otherORCID: 0000-0003-0198-5078
dc.identifier.otherORCID: /0000-0002-5313-9845/work/88320485
dc.identifier.otherORCID: /0000-0002-5555-4129/work/88321105
dc.identifier.urihttps://hdl.handle.net/2164/15638
dc.descriptionFunding Information: Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust [216767/Z/19/Z]. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL) Reference 104036/Z/14/Z). CG is supported by The Medical Research Council and The University of Edinburgh through the Precision Medicine Doctoral Training program. SRC is supported by the UK Medical Research Council [MR/R024065/1] and a National Institutes of Health (NIH) research grant R01AG054628. Acknowledgements The authors thank all of the STRADL and Generation Scotland participants for their time and effort taking part in this study. We would also like to thank all of the research assistants, clinicians and technicians for their help in the collecting this data.en
dc.format.extent10
dc.format.extent1621184
dc.language.isoeng
dc.relation.ispartofBrain, Behavior, and Immunityen
dc.subjectBrain morphologyen
dc.subjectBrain structureen
dc.subjectC-reactive proteinen
dc.subjectCRPen
dc.subjectDepressionen
dc.subjectInflammationen
dc.subjectMajor depressive disorderen
dc.subjectMethylationen
dc.subjectMRIen
dc.subjectWhite matter integrityen
dc.subjectR Medicineen
dc.subjectImmunologyen
dc.subjectEndocrine and Autonomic Systemsen
dc.subjectBehavioral Neuroscienceen
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectWellcome Trusten
dc.subject216767/Z/19/Zen
dc.subject104036/Z/14/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/R024065/1en
dc.subjectOtheren
dc.subjectR01AG054628en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleStructural brain correlates of serum and epigenetic markers of inflammation in major depressive disorderen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1016/j.bbi.2020.11.024
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85097058647&partnerID=8YFLogxKen


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