Show simple item record

dc.contributor.authorKilonzo, Mary Muenien
dc.contributor.authorVale, Luke Daviden
dc.contributor.authorCook, Jonathan Alistairen
dc.contributor.authorMilne, Anne Catherineen
dc.contributor.authorStephen, Audrey Isabellaen
dc.contributor.authorAvenell, Alisonen
dc.contributor.authorMAVIS Trial Groupen
dc.date.accessioned2007-07-31T14:05:11Z
dc.date.available2007-07-31T14:05:11Z
dc.date.issued2007
dc.identifier.citationKilonzon, M.M., Vale. L.D., Cook, J.A., Milne, A.C., Stephen, A.I, Avenall, A. and MAVIS Trial Group. (2007) Clinical Nutrition, 26(6)en
dc.identifier.issn0261-5614
dc.identifier.otherPURE: 388047en
dc.identifier.urihttp://hdl.handle.net/2164/151
dc.description.abstractBackground and Aims As people age there is a progressive dysregulation of the immune system that may lead to an increased risk of infections, which may precipitate hospital admission in people with chronic heart or respiratory diseases. Mineral and vitamin supplementation in older people could therefore influence infections in older people. However, the evidence from the available randomised controlled trials is mixed. The aim of the study was to assess the relative efficiency of multivitamin and multimineral supplementation compared with no supplementation. Methods Cost-utility analysis alongside a randomised controlled trial. Participants aged 65 years or over from six general practices in Grampian, Scotland were studied. They were randomised to one tablet daily of either a multivitamin and multimineral supplement or matching placebo. Exclusion criteria were: use of mineral, vitamin or fish oil supplements in the previous three months (one month for water soluble vitamins), vitamin B12 injection in the last three months. Results Nine hundred and ten participants were recruited (454 placebo and 456 supplementation). Use of health service resources and costs were similar between the two groups. The supplementation arm was more costly although this was not statistically significant (£15 per person, 95% CI -3.75 to 34.95). After adjusting for minimisation and baseline EQ-5D scores supplementation was associated with fewer QALYs per person (–0.018, 95% CI -0.04 to 0.002). It was highly unlikely that supplementation would be considered cost-effective. Conclusions The evidence from this study suggests that it is highly unlikely that supplementation could be considered cost-effective.en
dc.format.extent306458 bytes
dc.format.extent6 p.en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherElsevieren
dc.subjectDietaryen
dc.subjectSupplementen
dc.subjectVitaminsen
dc.subjectAgeden
dc.subjectMineralsen
dc.subjectCost effectivenessen
dc.subjectNutritionen
dc.subjectQuality of lifeen
dc.subjectRandomised controlled trialen
dc.subjectOral nutritional supplementationen
dc.subjectVitamins and Mineralsen
dc.subject.lccTX Home economicsen
dc.titleA cost-utility analysis of multivitamin and multimineral supplements in men and women aged 65 years and overen
dc.typeJournal Articleen
dc.typeTexten
dc.contributor.institutionUniversity of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciencesen
dc.description.versionPeer revieweden
dc.description.versionAuthor versionen
dc.identifier.doihttp://dx.doi.org/10.1016/j.clnu.2006.11.002


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record