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CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

dc.contributor.authorMcEwan, Andrew R
dc.contributor.authorDavidson, Connor
dc.contributor.authorHay, Elizabeth
dc.contributor.authorTurnbull, Yvonne
dc.contributor.authorErickson, Johanna Celene
dc.contributor.authorMarini, Pietro
dc.contributor.authorWilson, Dana
dc.contributor.authorMcIntosh, Andrew
dc.contributor.authorAdams, Mark J.
dc.contributor.authorMurgatroyd, Chris
dc.contributor.authorBarrett, Perry
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorMacKenzie, Alasdair
dc.date.accessioned2020-09-12T23:06:46Z
dc.date.available2020-09-12T23:06:46Z
dc.date.issued2021
dc.identifier157604471
dc.identifier5fb13a5c-c59e-4dc7-aff6-51bd26f8ad35
dc.identifier000519422800001
dc.identifier85082181124
dc.identifier32203157
dc.identifier.citationMcEwan , A R , Davidson , C , Hay , E , Turnbull , Y , Erickson , J C , Marini , P , Wilson , D , McIntosh , A , Adams , M J , Murgatroyd , C , Barrett , P , Delibegovic , M , Clarke , T-K & MacKenzie , A 2021 , ' CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake ' , Molecular Psychiatry , vol. 26 , pp. 2263–2276 . https://doi.org/10.1038/s41380-020-0707-7en
dc.identifier.issn1359-4184
dc.identifier.otherORCID: /0000-0003-3604-2950/work/76975742
dc.identifier.urihttps://hdl.handle.net/2164/15125
dc.descriptionWe would like to thank Wenlong Huang, Giuseppe D’Agostino and the staff of the University of Aberdeen Medical Research Facility for their help and advice with the animal tests. AMcE was funded by BBSRC project grant (BB/N017544/1) and EH was funded by Medical Research Scotland (PhD-719-2013). PB and DW are funded by the Scottish Government Rural and Environment Science and Analytical Services Division to the Rowett Institute. Association studies were conducted using the UK Biobank Resource: application number 4844 and was supported by a Wellcome Trust Strategic Award ‘Stratifying Resilience and Depression Longitudinally’ (STRADL) (Reference 104036/Z/14/Z). Dedicated to the memory of my dear brother Angus MacKenzie (1963–2018).en
dc.format.extent14
dc.format.extent9385678
dc.language.isoeng
dc.relation.ispartofMolecular Psychiatryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectUK Biobanken
dc.subjectCRISPR genome editingen
dc.subjecttissue-specific enhanceren
dc.subjectgalaninen
dc.subjectethanol intakeen
dc.subjectPKCen
dc.subjectEGR1en
dc.subjectmale anxietyen
dc.subjectDEPRESSIONen
dc.subjectREMOTE ENHANCERen
dc.subjectDISORDERSen
dc.subjectDEPENDENCEen
dc.subjectPARAVENTRICULAR NUCLEUSen
dc.subjectGALANINen
dc.subjectGENE-EXPRESSIONen
dc.subjectCONSUMPTIONen
dc.subjectRANGEen
dc.subjectHYPOTHALAMUSen
dc.subjectR Medicineen
dc.subjectPsychiatry and Mental healthen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectMolecular Biologyen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/N017544/1en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleCRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intakeen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Vice Principalsen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.description.statusPeer revieweden
dc.identifier.doi10.1038/s41380-020-0707-7
dc.date.embargoedUntil2020-09-13
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85082181124&partnerID=8YFLogxKen


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