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Klotho gene polymorphism, brain structure and cognition in early-life development

dc.contributor.authorde Vries, Clarisse Florence
dc.contributor.authorStaff, Roger
dc.contributor.authorNoble, Kimberly G.
dc.contributor.authorMuetzel, Ryan L.
dc.contributor.authorVernooij, Meike W.
dc.contributor.authorWhite, Tonya
dc.contributor.authorWaiter, Gordon David
dc.contributor.authorMurray, Alison Dorothy
dc.date.accessioned2020-04-01T10:25:01Z
dc.date.available2020-04-01T10:25:01Z
dc.date.issued2020-02-01
dc.identifier140154139
dc.identifierf1bc99b7-dfa4-4556-9cac-f6250f78c7e8
dc.identifier85056200527
dc.identifier30393836
dc.identifier000511797100021
dc.identifier.citationde Vries , C F , Staff , R , Noble , K G , Muetzel , R L , Vernooij , M W , White , T , Waiter , G D & Murray , A D 2020 , ' Klotho gene polymorphism, brain structure and cognition in early-life development ' , Brain Imaging and Behavior , vol. 14 , pp. 213-225 . https://doi.org/10.1007/s11682-018-9990-1en
dc.identifier.issn1931-7557
dc.identifier.otherORCID: /0000-0002-5313-9845/work/64218625
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976607
dc.identifier.urihttps://hdl.handle.net/2164/13941
dc.descriptionOpen access via Springer Compact Agreement Acknowledgements We thank the PING study participants who contributed to the research. The study was supported by the University of Aberdeen Development Trust and by the SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) Postdoctoral and Early Career Researcher Exchanges funding. The PING Study (National Institutes of Health Grant RC2DA029475) funded data collection and sharing for this project. PING is funded by the National Institute on Drug Abuse and the Eunice Kennedy Shriver National Institute of Child Health & Human Development. PING data are disseminated by the PING Coordinating Center at the Center for Human Development, University of California, San Diego. Data used in preparation of this article were obtained from the Pediatric Imaging, Neurocognition and Genetics Study (PING) database (http://ping.chd.ucsd.edu/). As such, the investigators within PING contributed to the design and implementation of PING and/or provided data but did not participate in analysis or writing of this report. A complete listing of PING investigators can be found at http://ping.chd.ucsd.edu/index.php?option=com_content&view=article&id=104&Itemid=134. The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. Neuroimaging was supported by the Netherlands Organization for Health Research and Development (ZonMw) TOP project number 91211021. We gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives and pharmacies in Rotterdam. We would like to thank Karol Estrada, Dr. Tobias A. Knoch, Anis Abuseiris, Luc V. de Zeeuw, and Rob de Graaf, for their help in creating GRIMP, BigGRID, MediGRID, and Services@MediGRID/D-Grid, [funded by the German Bundesministerium fuer Forschung und Technology; grants 01 AK 803 A-H, 01 IG 07015 G] for access to their grid computing resources. We thank Pascal Arp, Mila Jhamai, Marijn Verkerk, Manoushka Ganesh, Lizbeth Herrera and Marjolein Peters for their help in creating, managing and QC of the GWAS database. The general design of Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, ZonMw, the Netherlands Organisation for Scientific Research (NWO), the Ministry of Health, Welfare and Sport and the Ministry of Youth and Families.en
dc.format.extent13
dc.format.extent1177330
dc.language.isoeng
dc.relation.ispartofBrain Imaging and Behavioren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectKlothoen
dc.subjectPolymorphismen
dc.subjectDevelopmenten
dc.subjectCognitionen
dc.subjectBrainen
dc.subjectWHITE-MATTERen
dc.subjectVOLUMEen
dc.subjectCHILDRENen
dc.subjectFUNCTIONAL VARIANTen
dc.subjectCHILDHOOD IQen
dc.subjectCOHORTen
dc.subjectGENERATION Ren
dc.subjectSEX-DIFFERENCESen
dc.subjectASSOCIATIONen
dc.subjectSOCIOECONOMIC-STATUSen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectClinical Neurologyen
dc.subjectNeurologyen
dc.subjectPsychiatry and Mental healthen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectCognitive Neuroscienceen
dc.subjectRadiology Nuclear Medicine and imagingen
dc.subjectBehavioral Neuroscienceen
dc.subject.lccRC0321en
dc.titleKlotho gene polymorphism, brain structure and cognition in early-life developmenten
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Health Data Scienceen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.description.statusPeer revieweden
dc.identifier.doi10.1007/s11682-018-9990-1
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85056200527&partnerID=8YFLogxKen
dc.identifier.vol14en


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