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A New Generation of Selective Androgen Receptor Degraders : Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

dc.contributor.authorHwang, Dong-Jin
dc.contributor.authorHe, Yali
dc.contributor.authorPonnusamy, Suriyan
dc.contributor.authorMohler, Michael L.
dc.contributor.authorThiyagarajan, Thirumagal
dc.contributor.authorMcEwan, Iain J.
dc.contributor.authorNarayanan, Ramesh
dc.contributor.authorMiller, Duane D.
dc.date.accessioned2019-12-07T00:09:51Z
dc.date.available2019-12-07T00:09:51Z
dc.date.issued2019
dc.identifier141084022
dc.identifierf40d6add-6126-4906-89aa-c7f9202930a9
dc.identifier85059636744
dc.identifier.citationHwang , D-J , He , Y , Ponnusamy , S , Mohler , M L , Thiyagarajan , T , McEwan , I J , Narayanan , R & Miller , D D 2019 , ' A New Generation of Selective Androgen Receptor Degraders : Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity ' , Journal of Medicinal Chemistry , vol. 62 , no. 2 , pp. 491-511 . https://doi.org/10.1021/acs.jmedchem.8b00973en
dc.identifier.issn0022-2623
dc.identifier.otherMendeley: e33a8904-4279-3ba8-81b2-33bcabb8b594
dc.identifier.urihttps://hdl.handle.net/2164/13357
dc.descriptionThis research was supported by the Van Vleet Endowed Professorship (D.D.M.), and GTx, Inc. grant (R.N. and D.D.M.) We thank GTx, Inc. for supporting this project and Dr. Dejian Ma of UTHSC, College of Pharmacy for assistance with 2D NMR and HRMS experiments.en
dc.format.extent20
dc.format.extent2075694
dc.language.isoeng
dc.relation.ispartofJournal of Medicinal Chemistryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectstructure-activity relationshipen
dc.subjectselective androgen receptor degraderen
dc.subjectandrogen receptoren
dc.subjectandrogen receptor splice varianten
dc.subjectAR-V7en
dc.subjectAR escape mutantsen
dc.subjectAntagonisten
dc.subjectprostate canceren
dc.subjectAntiandrogen resistanceen
dc.subjectEnzalutamide resistanceen
dc.subjectCastration-resistant prostate canceren
dc.subjectN-terminal domainen
dc.subjectLigand binding domainen
dc.subjectProstate-specific antigenen
dc.subjectAR activation function domain-1en
dc.subjectR Medicine (General)en
dc.subjectDrug Discoveryen
dc.subjectMolecular Medicineen
dc.subjectSupplementary Dataen
dc.subjectsupplementary data availableen
dc.subject.lccR1en
dc.titleA New Generation of Selective Androgen Receptor Degraders : Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activityen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doihttps://doi.org/10.1021/acs.jmedchem.8b00973
dc.date.embargoedUntil2019-12-07
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85059636744&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/new-generation-selective-androgen-receptor-degraders-initial-design-synthesis-biological-evaluationen
dc.identifier.vol62en
dc.identifier.iss2en


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