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Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism

dc.contributor.authorBallard, Eloise
dc.contributor.authorWeber, Jakob
dc.contributor.authorMelchers, Willem J. G.
dc.contributor.authorTammireddy, Seshu
dc.contributor.authorWhitfield, Philip D.
dc.contributor.authorBrakhage, Axel A.
dc.contributor.authorBrown, Alistair J. P.
dc.contributor.authorVerweij, Paul E.
dc.contributor.authorWarris, Adilia
dc.date.accessioned2019-06-10T12:20:13Z
dc.date.available2019-06-10T12:20:13Z
dc.date.issued2019-09-01
dc.identifier144286426
dc.identifier10301b9e-eb43-40d7-b887-34f8f5f9e09c
dc.identifier85066289326
dc.identifier31128273
dc.identifier.citationBallard , E , Weber , J , Melchers , W J G , Tammireddy , S , Whitfield , P D , Brakhage , A A , Brown , A J P , Verweij , P E & Warris , A 2019 , ' Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism ' , Fungal Genetics and Biology , vol. 130 , pp. 98-106 . https://doi.org/10.1016/j.fgb.2019.05.005en
dc.identifier.issn1087-1845
dc.identifier.otherMendeley: 9c215a45-9963-354b-a9e8-9d6c56e19f09
dc.identifier.urihttp://hdl.handle.net/2164/12374
dc.descriptionEB, AB and AW are supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen. AB was also supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (BB/K017365/1) and the Medical Research Council (MR/M026663/1). JW and AAB were supported by the BMBF-funded project DrugBioTune in the frame of InfectControl2020 and the excellence graduate school Jena School of Microbial Communication. ST and PW acknowledge the support of the European Regional Development Fund, Scottish Funding Council and Highlands and Islands Enterprise. The work in this paper is funded by a BBSRC EASTBIO grant (BB/M010996/1) awarded to AW. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent9
dc.format.extent2628177
dc.language.isoeng
dc.relation.ispartofFungal Genetics and Biologyen
dc.subjectAspergillus fumigatusen
dc.subjectazole resistanceen
dc.subjectCRISPR-Cas9en
dc.subjectin-host adaptationen
dc.subjectergosterolen
dc.subjectErgosterolen
dc.subjectAzole resistanceen
dc.subjectIn-host adaptationen
dc.subjectR Medicine (General)en
dc.subjectGeneticsen
dc.subjectMicrobiologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectMR/M026663/1en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K017365/1en
dc.subjectBB/M010996/1en
dc.subjectWellcome Trusten
dc.subject097377en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleRecreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanismen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.identifier.doi10.1016/j.fgb.2019.05.005
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1087184519300751en
dc.identifier.urlhttp://www.mendeley.com/research/recreation-inhost-acquired-single-nucleotide-polymorphisms-crisprcas9-reveals-uncharacterised-gene-pen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85066289326&partnerID=8YFLogxKen


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